{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:07:14Z","timestamp":1784020034011,"version":"3.55.0"},"reference-count":30,"publisher":"ALUNA","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p>Aim: To find out new objective criteria for laser histological differential diagnosis of thyroid pathology based on the use of a digital method of layer-by-layer polarization-interference mapping of polarization ellipticity maps of microscopic images of native histological sections of thyroid biopsy.\r\nMaterials and Methods: Four groups of patients were studied: control group 1 \u2013 healthy donors (51 patients); study group 2 \u2013 patients with nodular goiter (51 patients); study group 3 \u2013 patients with autoimmune thyroiditis (51 patients); study group 4 \u2013 patients with papillary cancer (51 patients). Methods used: polarization-interference, statistical.\r\nResults: A brief theory and model concepts of the formation of structural optical anisotropy of polycrystalline networks of native histological sections of thyroid biopsy are considered. The structural and logical scheme of the method of polarization-interference layer-by-layer mapping of microscopic images of thyroid biopsies is presented. The statistical analysis of algorithmically reproduced maps of polarization ellipticity of experimental samples of biopsies of donors and patients with nodular goiter, autoimmune thyroiditis and papillary cancer was performed. Statistical objective markers for the differential diagnosis of thyroid pathology have been determined.\r\nConclusions: An excellent level (~93%-95%) of the balanced accuracy of differentiation of pathological conditions by the method of polarization-interference layer mapping was demonstrated.<\/jats:p>","DOI":"10.36740\/merkur202504102","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:40:47Z","timestamp":1757418047000},"page":"444","source":"Crossref","is-referenced-by-count":0,"title":["Digital differential diagnostics of thyroid pathology by interference scanning of ellipticity polarization maps of microscopic images of native histological sections"],"prefix":"10.36740","volume":"53","author":[{"given":"Oleksandr V.","family":"Bilookyi","sequence":"first","affiliation":[{"name":"BUKOVINIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurii Ye.","family":"Rohovyi","sequence":"additional","affiliation":[{"name":"BUKOVINIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurii A.","family":"Uschenko","sequence":"additional","affiliation":[{"name":"YURIY FEDKOVYCH CHERNIVTSI NATIONAL UNIVERSITY, CHERNIVTSI, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana V.","family":"Kinzerska","sequence":"additional","affiliation":[{"name":"YURIY FEDKOVYCH CHERNIVTSI NATIONAL UNIVERSITY, CHERNIVTSI, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriy M.","family":"Sklyarchuk","sequence":"additional","affiliation":[{"name":"YURIY FEDKOVYCH CHERNIVTSI NATIONAL UNIVERSITY, CHERNIVTSI, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viacheslav V.","family":"Bilookyi","sequence":"additional","affiliation":[{"name":"BUKOVINIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1. 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