{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:05:43Z","timestamp":1789160743292,"version":"build-2803163510"},"reference-count":25,"publisher":"ALUNA","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:p>Aim: To determine the association between the presence of comorbid pathology, the frequency and nature of extraintestinal manifestations, and changes in different health-related quality-of-life domains in patients with inflammatory bowel diseases.\nMaterials and Methods: A total of 248 patients with inflammatory bowel disease were examined, including 117 with Crohn\u2019s disease (Group I) and 131 with ulcerative colitis (Group II). The control group consisted of 82 apparently healthy individuals. Patients received inpatient treatment at healthcare institutions in Ivano-Frankivsk. The diagnosis was established in accordance with current clinical guidelines. Quality of life was assessed using the IBDQ questionnaire, while comorbidity was evaluated using the Cumulative Illness Rating Scale (CIRS) and the Charlson Comorbidity Index.\nResults: Patients with IBD demonstrated a statistically significant decrease in the overall IBDQ quality-of-life index compared with the control group (119.3\u00b110.48 in Crohn\u2019s disease and 127.4\u00b18.3 in ulcerative colitis versus 198.5\u00b112.6; p&lt;0.001), corresponding to a reduction of 39.9% and 35.9%, respectively. The most pronounced impairments were observed in the systemic and social domains, particularly in patients with Crohn\u2019s disease. A high prevalence of comorbid pathology was identified (73% in Crohn\u2019s disease and 82% in ulcerative colitis), along with a substantial burden of extraintestinal manifestations, characterized by predominant multisystem involvement in Crohn\u2019s disease and mental and vascular disorders in ulcerative colitis. The Charlson Comorbidity Index was higher in Crohn\u2019s disease (3.14\u00b10.27) compared with ulcerative colitis (2.93\u00b10.14; p\u22640.005), indicating a less favorable prognosis in this patient group. \nConclusions: Inflammatory bowel diseases are associated with a marked deterioration in quality of life and a high comorbid burden, substantiating the need for a comprehensive multidisciplinary approach to the management of such patients.<\/jats:p>","DOI":"10.36740\/merkur202604115","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:07:25Z","timestamp":1789157245000},"page":"478","source":"Crossref","is-referenced-by-count":0,"title":["Biopsychosocial model of inflammatory bowel diseases: The impact of multisystem comorbidity and mental health on patients\u2019 quality of life"],"prefix":"10.36740","volume":"54","author":[{"given":"Iryna","family":"Romash","sequence":"first","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Romash","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitalii","family":"Yatsynovych","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana","family":"Dzvonkovska","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uliana","family":"Reinert","sequence":"additional","affiliation":[{"name":"KRANKENHAUS DER BARMHERZIGEN BRUDER TRIER, TRIER, GERMANY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1. Kilic Y, Kamal S, Jaffar F et al. Prevalence of extraintestinal manifestations in inflammatory bowel disease: a systematic review and meta-analysis. Inflamm Bowel Dis. 2024;30(2):230-239. doi: 10.1093\/ibd\/izad061.","DOI":"10.1093\/ibd\/izad061"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"2. van Linschoten RCA, Visser E, Niehot CD et al. Systematic review: societal cost of illness of inflammatory bowel disease is increasing due to biologics and varies between continents. Aliment Pharmacol Ther. 2021;54(3):234-248. doi: 10.1111\/apt.16445.","DOI":"10.1111\/apt.16445"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"3. Brunet-Mas E, Garcia-Sague B, Vela E et al. Economic impact of inflammatory bowel disease in Catalonia: a population-based analysis. Ther Adv Gastroenterol. 2024;17:17562848231222344. doi: 10.1177\/17562848231222344.","DOI":"10.1177\/17562848231222344"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"4. Dorofeyev A, Tkach S, Dyadyk O, Prikhodko V. Features of the mucous barrier in functional bowel diseases and ulcerative colitis. Gastroenterology. 2022;56(2):89-94. doi:10.22141\/2308-2097.56.2.2022.493.","DOI":"10.22141\/2308-2097.56.2.2022.493"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"5. Isene R, Bernklev T, Hoie O et al. Extraintestinal manifestations in Crohn\u2019s disease and ulcerative colitis: results from a prospective, population-based European inception cohort. Scand J Gastroenterol. 2015;50(3):300-305. doi: 10.3109\/00365521.2014.991752.","DOI":"10.3109\/00365521.2014.991752"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"6. Uvarova K. Pozakyshkovi proyavy zapal\u02b9nykh zakhvoryuvan\u02b9 kyshechnyka. [Extraintestinal manifestations of inflammatory bowel diseases]. Aktual\u02b9ni problemy suchasnoyi medytsyny. 2020;(5):63-73. doi: 10.26565\/2617-409X-2020-5-08. (Ukrainian)","DOI":"10.26565\/2617-409X-2020-5-08"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"7. Essex M, Rios Rodriguez V, Rademacher J et al. Shared and distinct gut microbiota in spondyloarthritis, acute anterior uveitis, and Crohn\u2019s disease. Arthritis Rheumatol. 2024;76:48-58. doi: 10.1002\/art.42658.","DOI":"10.1002\/art.42658"},{"key":"ref7","unstructured":"8. Huzii O. Zapalni ta funktsionalni zakhvoriuvannia kyshechnyku: praktychnyi dosvid. [Inflammatory and functional bowel diseases: practical experience]. Ukrainskyi medychnyi chasopys. 2019;(6(1)):24-26. (Ukrainian)"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"9. Cherniavskyi V, Pavlovskyi L, Neverovskyi A et al. Vzaiemozviazok mizh hastroenterolohichnymy, shkiriannymy ta alerhichnymy zakhvoriuvanniamy: mify, zlovzhyvannia, realnist (ohliad literatury). [Relationship between gastroenterological, dermatological and allergic diseases: myths, misuse, reality (review)]. Simeina medytsyna. Yevropeiski praktyky. 2024;(2):89-94. doi:10.30841\/2786-720X.2.2024.307564. (Ukrainian)","DOI":"10.30841\/2786-720X.2.2024.307564"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"10. Romash IR, Romash IB, Pustovoyt MM. Features of social dysfunction, assessment of levels of social frustration and satisfaction with the quality of medical care in patients with schizophrenia on the background of somatic comorbidity. Wiad Lek. 2022;75(8):1876-1881. doi:10.36740\/WLek202208110.","DOI":"10.36740\/WLek202208110"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"11. Vernero M, Saibeni S, Scalvini D, et al. Prevalence and clinical impact of immune-mediated inflammatory diseases in patients with inflammatory bowel disease: results from a large retrospective observational study. J Clin Med. 2024;13(4):1019. doi: 10.3390\/jcm13041019.","DOI":"10.3390\/jcm13041019"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"12. Romash IR. Assessment of comorbid profile, quality of life and social functioning in patients with schizophrenia and schizotypal disorders. Med Perspect. 2023;(1):131-141. doi: 10.26641\/2307-0404.2023.1.276043.","DOI":"10.26641\/2307-0404.2023.1.276043"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"13. Tsagkaris C, Papazoglou AS, Romash IB et al. The bone-brain axis? Biopsychosocial aspects of orthopedics and a mental wellbeing action plan in musculoskeletal care. Wiad Lek. 2021;74(11):2829-2835.","DOI":"10.36740\/WLek202111126"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"14. Gao N, Qiao Z, Yan S, Zhu L. Evaluation of health-related quality of life and influencing factors in patients with Crohn disease. J Int Med Res. 2022;50(5):3000605221098868. doi: 10.1177\/03000605221098868.","DOI":"10.1177\/03000605221098868"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"15. Romash I, Sarapuk I, Romash I et al. From physical frailty to psychosocial maladaptation: predicting mental reserve and quality of life in patients with inflammatory bowel diseases. Ment Health Glob Chall J. 2025;8(1):222-234. doi: 10.56508\/mhgcj.v8i1.343.","DOI":"10.56508\/mhgcj.v8i1.343"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"16. Pallis AG, Mouzas IA, Vlachonikolis IG. The inflammatory bowel disease questionnaire: a review of its national validation studies. Inflamm Bowel Dis. 2004;10(3):261-269. doi: 10.1177\/26335565251365040.","DOI":"10.1097\/00054725-200405000-00014"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"17. Linn BS, Linn MW, Gurel L. Cumulative illness rating scale. J Am Geriatr Soc. 1968;16:622-626. doi: 10.1111\/j.1532-5415.1968.tb02103.x.","DOI":"10.1111\/j.1532-5415.1968.tb02103.x"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"18. Yarlas A, Maher S, Bayliss M et al. The inflammatory bowel disease questionnaire in randomized controlled trials of treatment for ulcerative colitis: systematic review and meta-analysis. J Patient Cent Res Rev. 2020;7(2):189-205. doi:10.17294\/2330-0698.1722.","DOI":"10.17294\/2330-0698.1722"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"19. Hudon C, Fortin M, Soubhi H. Abbreviated guidelines for scoring the cumulative illness rating scale (CIRS) in family practice. J Clin Epidemiol. 2007;60(2):212. doi:10.17294\/2330-0698.1722.","DOI":"10.1016\/j.jclinepi.2005.12.021"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"20. Lenti MV, Brera AS, Broglio G et al. Factors associated with comorbidity in hospitalized and non-hospitalized inflammatory bowel disease patients: a single- center, preliminary study. J Multimorb Comorb. 2025;15:26335565251365040. doi: 10.1177\/26335565251365040.","DOI":"10.1177\/26335565251365040"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"21. Fang LH, Zhang JQ, Huang JK, Tang XD. Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis. BMC Gastroenterol. 2025;25:13. doi: 10.1186\/s12876-024-03571-7.","DOI":"10.1186\/s12876-024-03571-7"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"22. Fu X, Wu H, Shu Y et al. Crohn disease but not ulcerative colitis increases the risk of acute pancreatitis: a 2-sample Mendelian randomization study. Medicine (Baltimore). 2024;103(23):e38317. doi: 10.1097\/MD.0000000000038317.","DOI":"10.1097\/MD.0000000000038317"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"23. Matiashova L, Tsagkaris C, Essar MY et al. \u201cAchilles in Ukraine: Concerns and priorities over the long-term implications of trauma\u201d. Int J Health Plann Manage. 2022;37(6):3369-3371. doi: 10.1002\/hpm.3562.","DOI":"10.1002\/hpm.3562"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"24. Kang H, Fischer IC, Esterlis I et al. Helping the helpers: mental health challenges of psychosocial support workers during the Russian-Ukrainian war. Disaster Med Public Health Prep. 2024;18:e95. doi: 10.1017\/dmp.2024.68.","DOI":"10.1017\/dmp.2024.68"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"25. Rayan RA, Zafar I, Romash IB. Healthcare system 4.0 perspectives on COVID-19 pandemic. Enabling Healthcare 4.0 for Pandemics. Hoboken (NJ): Wiley. 2021. doi: 10.1002\/9781119769088.ch2.","DOI":"10.1002\/9781119769088.ch2"}],"container-title":["Polski Merkuriusz Lekarski"],"original-title":[],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:07:33Z","timestamp":1789157253000},"score":1,"resource":{"primary":{"URL":"https:\/\/polskimerkuriuszlekarski.pl\/wp-content\/uploads\/library\/PolMerkurLek2026i4net.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,31]]},"published-print":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.36740\/merkur202604115","relation":{},"ISSN":["1426-9686"],"issn-type":[{"value":"1426-9686","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}