{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:04:44Z","timestamp":1785438284960,"version":"3.56.0"},"reference-count":0,"publisher":"ALUNA","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>is to study IL-1\u03b2, IL-6, IL-8, IL-10 blood serum levels and their relationship with colon tissue prostanoids in experimental ulcerative colitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Blood serum interleukins and colon tissue prostanoids were determined by enzyme immunosorbent assay on three groups of WAG population rats (1st control group \u2013 rectal saline injection; 2nd control group \u2013 50% ethanol injection; experimental group \u2013 injection of 2,4-dinitrobenzenesulfonic acid in 50% ethanol).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The increased levels of all interleukins both in 2nd control and experimental groups versus 1st control group were found.  No differences in IL-6, IL-8 levels between experimental and 2nd control groups were revealed. The relationships between interleukins and PGF2\u03b1, between interleukins and TXB2 in all groups, and the appearance of correlations between interleukins and PGE2, between interleukins and PGI2 in experimental group were observed. Negative correlations between IL-8 and COX-2 in 1st control, between IL-8 and COX-1 in both 2nd control and experimental groups were found.  Negative correlation between 8-epi-PGF2\u03b1 and IL-8, positive correlation between 8-epi-PGF2\u03b1 and PGF2\u03b1 in experimental group were revealed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results obtained testify the possible role of PGF2\u03b1 and 8-epi-PGF2\u03b1 in the development of ulcerative colitis and justify the importance of research on the link of 8-epi-PGF2\u03b1, IL-8, PGF2\u03b1 for understanding the mechanisms of development and progression of this disease. Increasing blood serum IL-8 level may be used as marker of reducing colon tissue COX-1 content in both ethanol- and 2,4-dinitrobenzenesulfonic acid-induced ulcerative colites<\/jats:p><\/jats:sec>","DOI":"10.36740\/wlek\/192139","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T11:36:48Z","timestamp":1731929808000},"page":"1712-1717","source":"Crossref","is-referenced-by-count":2,"title":["Blood serum interleukins levels and their relationship with colon tissue prostanoids in experimental ulcerative colitis"],"prefix":"10.36740","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-167X","authenticated-orcid":false,"given":"Iryna","family":"Vasylieva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-1587","authenticated-orcid":false,"given":"Oksana","family":"Nakonechna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9967-8927","authenticated-orcid":false,"given":"Liudmyla","family":"Popova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2798-4575","authenticated-orcid":false,"given":"Natalia","family":"Yarmysh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-7165","authenticated-orcid":false,"given":"Anastasiia","family":"Bezrodna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-9725","authenticated-orcid":false,"given":"Nataliia","family":"Pustova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2024,11,3]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-192139-115970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-192139-115970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T11:36:57Z","timestamp":1731929817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Blood-serum-interleukins-levels-and-their-relationship-with-colon-tissue-prostanoids,192139,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,3]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024]]}},"alternative-id":["192139"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/192139","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,3]]}}}