{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T05:18:57Z","timestamp":1738387137747,"version":"3.35.0"},"reference-count":27,"publisher":"ALUNA","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Aims: To evaluate the expression levels of Sox10 in tissues of bladder tumor and to prove the correlation between Sox10 expression and clinicopathological characteristics of bladder tumors, including patient age, sex, tumor grade, and muscle invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Material and Method: Forty formalin fixed paraffin embedded FFPE tissue blocks gathered by transurethral resection of bladder tumor are collected from teaching hospitals at Al-Najaf governorate. Those blocks were stained by hematoxylin and eosin. The histopathological characteristics were examined and immunostained by SOX-10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results: An assessment of expression of SOX-10 in carcinoma of urothelium showed that a test of SOX-10 was (positive) in five samples of urothelial carcinoma, while SOX-10 test was (negative) in thirty-five samples of urothelial carcinoma. Correlation of SOX-10 with other variables (age, sex, and grade) was a statistically non-significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Conclusion: SOX-10 is an Immunohistochemical sensitive marker for the diagnosis of urothelial carcinoma. SOX-10 expression appeared to be non-significant relation with age, gender and histopathological parameters and its expression has been showed to be lost or decreased in substantial proportion in relation to urothelial carcinoma. This variation or down regulation of SOX-10 is correlated with higher tumor grade and stage.<\/jats:p><\/jats:sec>","DOI":"10.36740\/wlek\/195857","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T08:40:46Z","timestamp":1738312846000},"page":"2481-2486","source":"Crossref","is-referenced-by-count":0,"title":["Immunohistochemical Evaluation of SOX-10 in Patients with Urinary Bladder Cancer"],"prefix":"10.36740","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5281-8857","authenticated-orcid":false,"given":"Randa Saad","family":"Hameed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-2419","authenticated-orcid":false,"given":"Ghufran Salman","family":"Abd Alhussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4997-5549","authenticated-orcid":false,"given":"Rihab Hameed","family":"Almudhafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-5354","authenticated-orcid":false,"given":"Liwaa Hussein","family":"Mahdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"ref-1358305","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref-1358306","doi-asserted-by":"crossref","unstructured":"Apolo AB, Vogelzang NJ, Theodorescu D. New and promising strategies in the management of bladder cancer. Am Soc Clin Oncol. 2015; (35): 105-112.","DOI":"10.14694\/EdBook_AM.2015.35.105"},{"key":"ref-1358307","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28394"},{"key":"ref-1358308","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa.021423"},{"key":"ref-1358309","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.5.52"},{"key":"ref-1358310","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM.22818"},{"key":"ref-1358311","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.05.008"},{"key":"ref-1358312","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.01.087"},{"key":"ref-1358313","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30512-8"},{"key":"ref-1358314","doi-asserted-by":"publisher","DOI":"10.3390\/ijms.242417600"},{"key":"ref-1358315","doi-asserted-by":"publisher","DOI":"10.3390\/cancers.15235704"},{"key":"ref-1358316","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0539-RA"},{"key":"ref-1358317","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2018.4423"},{"key":"ref-1358318","doi-asserted-by":"publisher","DOI":"10.3390\/curronco.l30030197"},{"key":"ref-1358319","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1164401"},{"key":"ref-1358320","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.09.020"},{"key":"ref-1358321","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206442"},{"key":"ref-1358322","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.07.034"},{"key":"ref-1358323","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2208"},{"key":"ref-1358324","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22855"},{"key":"ref-1358325","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107114"},{"key":"ref-1358326","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03432-6"},{"key":"ref-1358327","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24351"},{"key":"ref-1358328","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14959"},{"key":"ref-1358329","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-017-1641-2"},{"key":"ref-1358330","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22586"},{"key":"ref-1358331","doi-asserted-by":"crossref","unstructured":"Yin H, Qin C, Zhao Y et al. SOX10 is over-expressed in bladder cancer and contributes to the malignant bladder cancer cell behaviors. Clin Transl Oncol. 2017;19:1035\u20131044.","DOI":"10.1007\/s12094-017-1641-2"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-195857-120990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-195857-120990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T08:42:25Z","timestamp":1738312945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Immunohistochemical-Evaluation-of-SOX-10-in-Patients-with-Urinary-Bladder-Cancer,195857,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024]]}},"alternative-id":["195857"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/195857","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]}}}