{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T05:19:10Z","timestamp":1738387150634,"version":"3.35.0"},"reference-count":10,"publisher":"ALUNA","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"Aim<\/jats:title>Even though Leydig cell tumor (LCT) represents the most common neoplasia among testicular sex cord\u2013stromal tumors (SCSTs), it is a rare condition, comprising 1%\u20102% of all testicular tumors, with a 10% risk of malignancy most commonly located in retroperitoneal lymph nodes. LCTs may demonstrate various clinical manifestations \u2013 from asymptomatic intratesticular swelling through nonspecific symptoms such as loss of libido, impotence or infertility, up to feminizing or virilizing syndromes due to hormonal activity of the tumor. This article presents a case of Leydig cell tumor that was associated with azoospermia what have rarely been reported worldwide.<\/jats:p><\/jats:sec>Material and methods<\/jats:title>does not concern<\/jats:p><\/jats:sec>Case report<\/jats:title>A 27-year-old male presented to the urologist with one-month history of palpable testicular mass. Imaging tests revealed a well demarcated solid focal lesion in the upper pole of the left testicle and semen analysis indicated azoospermia. Due to small testicular lesion, negative serum markers and negative reports for malignancy in MRI imaging, testis-sparing surgery (TSS) was performed. The final histopathological examination revealed a Leydig cells tumor positive for inhibin, calretinin and MelanA. Six month after the surgery spermatogenic function was partially restored what have rarely been reported in scientific papers.<\/jats:p><\/jats:sec>Summary<\/jats:title>This case indicates that TSS may provide an effective way of semen quality improvement, although further research is required.<\/jats:p><\/jats:sec>","DOI":"10.36740\/wlek\/196469","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T08:40:46Z","timestamp":1738312846000},"page":"2563-2565","source":"Crossref","is-referenced-by-count":0,"title":["Fertility before and after treatment of the patient with Leydig cell tumor \u2013 case report"],"prefix":"10.36740","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4578-233X","authenticated-orcid":false,"given":"Pawe\u0142","family":"Miklis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7890-2686","authenticated-orcid":false,"given":"Monika","family":"Rudzi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5233-5446","authenticated-orcid":false,"given":"Micha\u0142","family":"Sulewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"ref-1358743","doi-asserted-by":"crossref","unstructured":"Rosen A, Drazer M, Eggener S. 837 GLOBAL TRENDS IN TESTICULAR CANCER INCIDENCE AND MORTALITY. Journal of Urology. 2010 Apr;183(4S).","DOI":"10.1016\/j.juro.2010.02.2339"},{"key":"ref-1358744","doi-asserted-by":"crossref","unstructured":"Chia VM, Quraishi SM, Devesa SS, Purdue MP, Cook MB, McGlynn KA. International trends in the incidence of testicular cancer, 1973-2002. Cancer Epidemiology Biomarkers and Prevention. 2010 May;19(5):1151\u20139.","DOI":"10.1158\/1055-9965.EPI-10-0031"},{"key":"ref-1358745","doi-asserted-by":"crossref","unstructured":"Kowalik K, Hetman K, Kasperowicz K, Modrzejewski A. Sex cord-stromal tumors of the testis \u2014 a rare group of benign and malignant gonadal neoplasms. Literature review. Oncology in Clinical Practice. 2024 Jan 16;.","DOI":"10.5603\/ocp.97184"},{"key":"ref-1358746","doi-asserted-by":"crossref","unstructured":"Al-Agha OM, Axiotis CA. An In-Depth Look at Leydig Cell Tumor of the Testis. Vol. 131, Arch Pathol Lab Med. 2007.","DOI":"10.5858\/2007-131-311-AILALC"},{"key":"ref-1358747","doi-asserted-by":"crossref","unstructured":"Carmignani L, Salvioni R, Gadda F, Colecchia M, Gazzano G, Torelli T, et al. Long-Term Followup and Clinical Characteristics of Testicular Leydig Cell Tumor: Experience With 24 Cases. Journal of Urology. 2006 Nov;176(5):2040\u20133.","DOI":"10.1016\/j.juro.2006.07.005"},{"key":"ref-1358748","unstructured":"Ugboma HAA, Aburoma HLS. Public awareness of testicular cancer and testicular self-examination in academic environments: A lost opportunity. Clinics. 2011;66(7):1125\u20138."},{"key":"ref-1358749","doi-asserted-by":"crossref","unstructured":"Mooney KL, Kao CS. A Contemporary Review of Common Adult Non\u2013germ Cell Tumors of the Testis and Paratestis. Surg Pathol Clin. 2018 Dec;11(4):739\u201358.","DOI":"10.1016\/j.path.2018.07.002"},{"key":"ref-1358750","doi-asserted-by":"crossref","unstructured":"MINEUR P, COOMAN S DE, HUSTIN J, VERHOEVEN G, HERTOGH R DE. Feminizing Testicular Leydig Cell Tumor: Hormonal Profile before and after Unilateral Orchidectomy*. J Clin Endocrinol Metab. 1987 Apr;64(4):686\u201391.","DOI":"10.1210\/jcem-64-4-686"},{"key":"ref-1358751","doi-asserted-by":"crossref","unstructured":"Hibi H, Yamashita K, Sumitomo M, Asada Y. Leydig cell tumor of the testis, presenting with azoospermia. Reprod Med Biol. 2017 Oct 1;16(4):392\u20135.","DOI":"10.1002\/rmb2.12046"},{"key":"ref-1358752","doi-asserted-by":"crossref","unstructured":"Kong Q, Yu Y, Tian T, Zhang H, Sun M, Liu R, et al. Leydig cell tumor of a testis with azoospermia: A case report and literature review. Medicine (United States). 2020 Sep 4;99(36):E22085.","DOI":"10.1097\/MD.0000000000022085"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-196469-121003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-196469-121003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T08:43:51Z","timestamp":1738313031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Fertility-before-and-after-treatment-of-the-patient-with-Leydig-cell-tumor-case-report,196469,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024]]}},"alternative-id":["196469"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/196469","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]}}}