{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:11:16Z","timestamp":1747887076905,"version":"3.41.0"},"reference-count":0,"publisher":"ALUNA","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To improve early diagnosis by analyzing the pathological pattern of \"mother-newborn\" in newborns.\nMaterials and Methods: The study group included newborns with a diagnosis of \u201cInfection specific to the perinatal period, unspecified\u201d (P39,9, n=64), born to mothers (age 31,31 \u00b1 2,08 years) with a complicated diagnosis and a control group (n=31) of infants. \nResults: Clinical manifestations in newborns mainly included involvement of the central nervous system (57,8%), cardiovascular system (12,0%), congenital heart defects (2,8%), jaundice (11,0%), hepatosplenomegaly (5,2%), exanthema (9,0%), hypothermia (70,6%). Markers of inflammatory response confirmed an increase in the level of IL-1, a significant increase in IL-6 levels, the level of IL-8 in the studied contingent also significantly differs from the data of the control group, the level \u03b3-IFN also exceeded the reference values by 2,4 times. Hypoxic-ischemic encephalopathy was detected in 63 infants (57,8%) and intracranial hemorrhage was diagnosed in 25 (22,9%) infants. \nConclusions: The values of cytokine profile parameters (IL-1, IL-6, IL-8, IL-10) on the first day of life varied within the reference values, but with significant differences from the values of the control group, which were 9,24; 20; 11 times, respectively.  The levels of inflammatory mediators (\u03b3-IFN, procalcitonin, neopterin, TNF-\u03b1, Pg E2) significantly differed from the data of the control group and exceeded the upper limit of reference values by 2,4; 40; 8,9; 25; 3,5 times, respectively.<\/jats:p>","DOI":"10.36740\/wlek\/203889","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T11:21:43Z","timestamp":1747826503000},"page":"783-789","source":"Crossref","is-referenced-by-count":0,"title":["Clinical manifestation, laboratory and instrumental characteristics of infants born to mothers with a complicated anamnesis"],"prefix":"10.36740","author":[{"given":"Olesya M.","family":"Horlenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriy Yu.","family":"Chuhran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella B.","family":"Kossey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria  V.","family":"Ivano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariya A.","family":"Derbak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr D.","family":"Symulyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lybov Yu.","family":"Pushkash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025,4,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-203889-125377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-203889-125377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T11:21:47Z","timestamp":1747826507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Clinical-manifestation-laboratory-and-instrumental-characteristics-of-infants-born,203889,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"alternative-id":["203889"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/203889","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}