{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:11:17Z","timestamp":1747887077317,"version":"3.41.0"},"reference-count":0,"publisher":"ALUNA","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To investigate the correlations between the level of IL1\u03b2 mRNA gene expression and the type and duration of infertility and to study the levels of IL1\u03b2 mRNA gene expression in women with endometriosis associated with infertility. \nMaterials and Methods: For mRNA gene expression analysis IL1\u03b2 and determination of relative normalized mRNA expression IL1\u03b2 used the real-time reverse transcription polymerase chain reaction method (RT-PCR).. Examined group consists of 30 infertile women undergoing assisted reproductive technologies. The main group consisted of 20 women diagnosed with endometriosis undergoing assisted reproductive technologies. The control group consisted of 10 healthy women. \nResults: In the main group, the level of IL1\u03b2 mRNA gene expression before preparing was 26.7877\u00b10.01, which was significantly higher than the level after preparing (0.1610\u00b10.01* ). \nAnalized results, it\u2019s found out that Mean level of mRNA IL1\u03b2 in women with endometriosis  associated infertility 1-st degree is 8.53 c.u., at the same time Mean level of mRNA IL1\u03b2 in women with endometriosis associated infertility 2-nd degree is 1.0 c.u. \nConclusions: The inclusion of probiotics in a comprehensive regimen of preparation for assisted reproductive technologies leads to a noticeable improvement in the patient's well-being.<\/jats:p>","DOI":"10.36740\/wlek\/203893","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T11:21:43Z","timestamp":1747826503000},"page":"828-837","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between MRNA IL1\u0392 and type, duration of infertility in women with endometriosis on the stage preparing to assisted reproductive technologies using probiotics"],"prefix":"10.36740","author":[{"given":"Oksana V.","family":"Bakun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina V.","family":"Dyak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana V.","family":"Kolesnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetiana","family":"Protsak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yevheniia A.","family":"Dudka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025,4,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-203893-125383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-203893-125383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T11:21:49Z","timestamp":1747826509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Correlation-between-MRNA-IL1-and-type-duration-of-infertility-in-women-with-endometriosis,203893,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"alternative-id":["203893"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/203893","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}