{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:32:22Z","timestamp":1789144342750,"version":"build-2803163510"},"reference-count":0,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of the study is to study changes in Lp-PLA2 in the blood of patients in the early recovery period of atherothrombotic stroke depending on the degree of stenosis and type of atherosclerotic plaque.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A clinical and laboratory analysis of 130 patients in the early recovery period of atherothrombotic stroke was conducted. Among those examined were 69 men and 61 women aged (60.42\u00b17.4) years. The control group consisted of 30 practically healthy persons (16 men and 14 women) without a history of severe somatic pathology, aged (58.7\u00b16.3) years. Ultrasound scanning of the vessels of the neck was performed on a Siemens Acuson X 300 device. The amount of lipoprotein-associated phospholipase A2 (Lp-PLA2) was determined by the immunoenzymatic method. STATISTICA 8 software was used for statistical processing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all examined patients, an increase in the content of Lp-PLA2 in the blood up to 260 (220.4; 295.7) ng\/ml was found compared to individuals of the control group (p&lt;0.05). Increased levels of Lp-PLA2 in stroke patients were associated with an increased degree of atherosclerotic stenosis and depended on the type of atherosclerotic plaque, reflecting its instability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased concentrations of Lp-PLA2 in patients with cerebral atherosclerosis can be considered as circulating biomarkers of atherosclerotic plaque vulnerability. Patients in the early recovery period of an ischemic stroke with a soft atherosclerotic plaque according to ultrasound data in combination with an increase in Lp-PLA2 indicators in the blood belong to the group of high risk of developing a repeated stroke.<\/jats:p><\/jats:sec>","DOI":"10.36740\/wlek\/204797","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T08:49:23Z","timestamp":1754642963000},"page":"1119-1124","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic value of lipoprotein-associated phospholipase A2 in patients in the early recovery period of atherothrombotic stroke."],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-4501","authenticated-orcid":false,"given":"Olga Jaroslavivna","family":"Mykhaloiko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-7921","authenticated-orcid":false,"given":"Viktoriya Anatolyivna","family":"Gryb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1154-3241","authenticated-orcid":false,"given":"Ivanna-Romana Mykolaivna","family":"Fabryka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-7419","authenticated-orcid":false,"given":"Oleksandra Ihorivna","family":"Hotsaniuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-3585","authenticated-orcid":false,"given":"Ulyana Petrivna","family":"Shalamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-622X","authenticated-orcid":false,"given":"Tatyana Ivan\u0456vna","family":"Salyzhyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-1806","authenticated-orcid":false,"given":"Igor Jaroslavovich","family":"Mykhaloiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2025,7,25]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-204797-127416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-204797-127416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T08:49:28Z","timestamp":1754642968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Diagnostic-value-of-lipoprotein-associated-phospholipase-A2-in-patients-in-the-early,204797,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"alternative-id":["204797"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/204797","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]}}}