{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T10:40:11Z","timestamp":1756118411712,"version":"3.44.0"},"reference-count":0,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the intensity of posttraumatic oxidative stress (OS) in patients with mild explosive traumatic brain injury (METBI) complicated by acoustic barotrauma and its association with sensorineural hearing loss (SHL) occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This study included 43 patients with METBI form October 2023 to May 2024. Subjective tinnitus was assessed using the Tinnitus Handicap Inventori scale. Determination of markers of oxidative modification of proteins - aldehyde phenylhydrazones, carboxy phenylhydrazones. The state of the antioxidant system was assessed by the level of total thiols and reduced glutathione in the blood plasma by fluorometric method. Determination of the number of stable metabolites of nitric oxide in the blood  was carried out according to the Griess method. The expression of morphological changes in the head vascular network was studied using computer histomorphometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>METBI initiated an increase in OS markers in blood: aldehyde phenylhydrazone (APH) by 53.54% (p&lt;0.05), carboxy phenylhydrazone (CPH) - by 50.51% (p&lt;0.05) and with a deficiency of the antioxidant system of reduced glutathione by 47.4% (p&lt;0.05), total thiols by 61.7% (p&lt;0.05), decrease in the level of nitric oxide in blood by 54.22% (p&lt;0.05), which led to microcirculatory disorder. A direct correlation was established between the frequency of SHL and an increase of APH (r=+0.72, p&lt;0.05), CPH (r=+0.66, p&lt;0.05) and an inverse correlation with a reduced glutathione deficiency (r=-0.85, p&lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An imbalance of antioxidant protection led to significant microcirculatory disorders. The data obtained are important for the neutralization of the effect of damaging factors of OS on the inner ear microcirculation.<\/jats:p><\/jats:sec>","DOI":"10.36740\/wlek\/204995","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T09:59:06Z","timestamp":1756115946000},"page":"1265-1271","source":"Crossref","is-referenced-by-count":0,"title":["Influence of oxidative stress caused by a blast wave in acoustic barotrauma on the auditory analyzer."],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6410-7769","authenticated-orcid":false,"given":"Olga","family":"Rzhevska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2918-4547","authenticated-orcid":false,"given":"Vasyl","family":"Troian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-0088","authenticated-orcid":false,"given":"Irina","family":"Sinaiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4252-8690","authenticated-orcid":false,"given":"Olena","family":"Lobova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-8063","authenticated-orcid":false,"given":"Olena","family":"Solomko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-2728","authenticated-orcid":false,"given":"Kseniia","family":"Zolotarov\u0430","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3563-0371","authenticated-orcid":false,"given":"Kateryna","family":"Shtrakh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025,7,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-204995-128053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-204995-128053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T09:59:09Z","timestamp":1756115949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Influence-of-oxidative-stress-caused-by-a-blast-wave-in-acoustic-barotrauma-on-the,204995,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025]]}},"alternative-id":["204995"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/204995","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]}}}