{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:17:24Z","timestamp":1777447044548,"version":"3.51.4"},"reference-count":0,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: The purpose of this study was to analyze current literature data regarding the involvement of the macrophage population in the processes of reparative\nosteogenesis in the mandible.\nMaterials and Methods: The authors conducted a review of scientific sources available in databases such as PubMed, Web of Science, Scopus, Google Scholar,\nand ResearchGate.\nConclusions: It was shown by the authors that macrophages play a crucial role at all stages of reparative osteogenesis in the mandible. Their high degree\nof plasticity enables them to adapt to changes in the microenvironment by dynamically shifting their phenotype (from M1 to M2 and vice versa). Alterations\nin the morphofunctional state of macrophages and an imbalance between M1 and M2 populations under pathological conditions lead to disruptions in the\nreparative osteogenesis process. Currently, macrophages are recognized as key therapeutic targets for modulating reparative osteogenesis in cases of mandibular\nbone pathology.<\/jats:p>","DOI":"10.36740\/wlek\/205957","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T08:49:23Z","timestamp":1754642963000},"page":"1176-1181","source":"Crossref","is-referenced-by-count":2,"title":["MACROPHAGES AND THEIR INVOLVEMENT IN MANDIBULAR REPARATIVE OSTEOGENESIS: CURRENT INSIGHTS"],"prefix":"10.36740","author":[{"given":"Igor S.","family":"Brodetskyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislav A.","family":"Malanchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliia M.","family":"Savielieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mykhailo S.","family":"Myroshnychenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yevheniia A.","family":"Hromko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrii A.","family":"Boiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liudmyla O.","family":"Brodetska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaroslava \u0410.","family":"Kulbashna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey B.","family":"Brodetskyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halyna V.","family":"Zhurakovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025,7,25]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-205957-127423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-205957-127423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T08:49:30Z","timestamp":1754642970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/MACROPHAGES-AND-THEIR-INVOLVEMENT-IN-MANDIBULAR-REPARATIVE-OSTEOGENESIS-CURRENT-INSIGHTS,205957,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"alternative-id":["205957"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/205957","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]}}}