{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:54:26Z","timestamp":1777553666095,"version":"3.51.4"},"reference-count":0,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To investigate the relationships of kidney function with clinical and laboratory parameters in multiple myeloma (MM) patients.\nMaterials and Methods: A cross-sectional study involved 105 MM patients. Data included clinical manifestations and standard laboratory parameters.\nKidney function was assessed via estimated glomerular filtration rate (eGFR), serum creatinine, urea, uric acid (UA), calcium (Ca), and albumin-to-creatinine\nratio (ACR). The markers of MM activity and burden included M-protein, beta-2 microglobulin (\u03b22m), albumin, hemoglobin (Hb), lactate dehydrogenase (LDH)\nand platelets (PLT). Rank biserial correlation assessed associations between symptoms and laboratory parameters. Rank-based canonical correlation analysis\n(RCCA) explored the multivariate relationship between six kidney function indicators and six MM-related markers.\nResults: Common laboratory abnormalities included elevated \u03b22m (90,5 %) and anemia (indicated by low Hb in 52,4 % of patients). Frequent symptoms\nincluded bone pain (71,4 %) and weakness (68,6 %). Symptoms like weakness\/breathlessness correlated significantly with (\u03b22m, M-protein) and renal impairment\n(creatinine, ACR, eGFR). RCCA identified one significant canonical correlation (R1=0,497; p=0,013), linking impaired renal function (characterized by low\neGFR, high ACR, creatinine and urea) with a myeloma profile indicative of disease activity and burden (high \u03b22m, low Hb, low albumin, and high M-protein).\nConclusions: The study confirms a significant multivariate association between a profile of impaired renal function and markers reflecting MM activity, hematopoietic\nsuppression and systemic burden. These findings underscore the multifactorial nature of MM-related kidney injury and highlight the clinical utility\nof monitoring key laboratory markers (including eGFR, ACR, creatinine, \u03b22m, Hb and albumin) alongside clinical evaluation for comprehensive assessment\nand management of MM patients.<\/jats:p>","DOI":"10.36740\/wlek\/207359","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T08:49:23Z","timestamp":1754642963000},"page":"1019-1025","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and laboratory correlates of kidney function in multiple myeloma patients"],"prefix":"10.36740","author":[{"given":"Halyna R.","family":"Savuliak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladyslav O.","family":"Bardash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetiana A.","family":"Maksymets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mykhaylo V.","family":"Perepelytsya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoryana M.","family":"Kit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia V.","family":"Karpyshyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen Ya.","family":"Sklyarov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025,7,25]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-207359-127401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-207359-127401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T08:49:24Z","timestamp":1754642964000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Clinical-and-laboratory-correlates-of-kidney-function-in-multiple-myeloma-patients,207359,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"alternative-id":["207359"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/207359","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]}}}