{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:08:37Z","timestamp":1759018117091,"version":"3.44.0"},"reference-count":0,"publisher":"ALUNA","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>The ketogenic diet, characterized by high fat and low carbohydrate intake, has gained increasing attention for its potential therapeutic effects on a range of neurological disorders. Originally developed to mimic the metabolic effects of fasting, the diet induces ketosis and alters brain energy metabolism, offering neuroprotective benefits. This comprehensive review synthesizes current literature on the efficacy, mechanisms, and safety of the ketogenic diet in epilepsy, Alzheimer\u2019s disease, migraine, Parkinson\u2019s disease, depression, and multiple sclerosis. Evidence suggests that the ketogenic diet modulates neurotransmitter levels, improves mitochondrial function, reduces oxidative stress, and alters neuroinflammatory pathways. Clinical studies have demonstrated promising outcomes, particularly in drug-resistant epilepsy and early-stage Alzheimer\u2019s disease. However, adherence challenges and potential adverse effects\u2014including gastrointestinal disturbances and metabolic complications\u2014highlight the need for cautious implementation and further research. This review underscores the importance of expanding clinical investigations to fully elucidate the diet\u2019s long-term neurological implications. \nKeywords: ketogenic diet, epilepsy, Alzheimer's disease, migraine, Parkinson\u2019s disease, depression, multiple sclerosis, neurological disorders.<\/jats:p>","DOI":"10.36740\/wlek\/208442","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T18:13:10Z","timestamp":1758996790000},"page":"1664-1669","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Neurological Impacts of the Ketogenic Diet: A Comprehensive Review"],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7382-9690","authenticated-orcid":false,"given":"Piotr","family":"Kucharczyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5395-7366","authenticated-orcid":false,"given":"Kinga","family":"Szczepanik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2284-1221","authenticated-orcid":false,"given":"Karolina","family":"Parz\u0119cka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1208-2007","authenticated-orcid":false,"given":"Anna","family":"\u017bera\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5495-4670","authenticated-orcid":false,"given":"Mateusz","family":"Michalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8355-2262","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"Kusy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0533-9386","authenticated-orcid":false,"given":"Olaf","family":"Domaradzki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1776-8862","authenticated-orcid":false,"given":"Wojciech","family":"Bie\u0144kowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1224-3251","authenticated-orcid":false,"given":"Julia","family":"Charkot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025,8,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-208442-129162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-208442-129162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T18:13:16Z","timestamp":1758996796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Exploring-the-Neurological-Impacts-of-the-Ketogenic-Diet-A-Comprehensive-Review,208442,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025]]}},"alternative-id":["208442"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/208442","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,30]]}}}