{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:40:18Z","timestamp":1787784018184,"version":"build-2784847793"},"reference-count":0,"publisher":"ALUNA","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluates the hepatoprotective effect of Ocimum basilicum extract in minimizing ethanol-induced liver damage in rats by its action on pro-inflammatory cytokine levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A total of 120 male rats were divided into four groups: a control group, an ethanol-induced liver damage group, a low-dose basil treatment group, and a high-dose basil treatment group. Pro-inflammatory cytokines (TNF-\u03b1, IL-6, IL-1\u03b2) were measured using ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ethanol exposure group showed significantly elevated TNF-\u03b1 (548.8 \u00b1 83.78 pg\/mL), IL-6 (410.3 \u00b1 167.7 pg\/mL), and IL-1\u03b2 (373.1 \u00b1 127.7 pg\/mL) compared to the control group. Basil supplementation, particularly at high doses (100 mg\/kg), effectively reduced these cytokines, with TNF-\u03b1 (316.4 \u00b1 57.37 pg\/mL) and IL-6 (133.9 \u00b1 86.76 pg\/mL) levels approaching control values. IL-1\u03b2 was also significantly reduced (152.3 \u00b1 79.37 pg\/mL) but remained slightly elevated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that Ocimum basilicum extract has potent hepato protective and anti-inflammatory properties, making it a promising natural therapeutic agent for alcohol-induced liver damage.<\/jats:p><\/jats:sec>","DOI":"10.36740\/wlek\/208443","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T18:13:10Z","timestamp":1758996790000},"page":"1522-1529","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Ocimum basilicum Herbs Extract on Pro-Inflammatory Cytokines in Ethanol-Induced Liver Damage in Rats"],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-0101","authenticated-orcid":false,"given":"Hussein Talib","family":"Abdullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-5535","authenticated-orcid":false,"given":"Almas M.","family":"Al-Bayati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5796-358X","authenticated-orcid":false,"given":"Abbas Najm Aldin","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-2678","authenticated-orcid":false,"given":"Karima Akool","family":"AlSalihi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-3037","authenticated-orcid":false,"given":"Hayder H.","family":"Abed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2025,8,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-208443-129176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-208443-129176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T18:13:12Z","timestamp":1758996792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Effect-of-Ocimum-basilicum-Herbs-Extract-on-Pro-Inflammatory-Cytokines-in-Ethanol,208443,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025]]}},"alternative-id":["208443"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/208443","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,30]]}}}