{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T10:40:13Z","timestamp":1756118413088,"version":"3.44.0"},"reference-count":0,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To study peculiarities of the state of extracellular matrix in testicular embryonal carcinoma.\nMaterials and Methods: Samples of testicular embryonal carcinoma tissue were collected from 3 groups of patients (group \u00ab1\u00bb \u2013 stages T1N0S0-2, group \u00ab2\u00bb\nT1N0S0-2\n\u2013 T2N1-3S0-2, group \u00ab3\u00bb \u2013 T2-3N0-3S0-2 with distant metastases) to assess the state of its extracellular matrix investigating MMP-1, MMP-3 and MMP-9 expression.\n2N1-3S0-\nT2-3N0-3S0-2\nResults: The levels of MMP-1, MMP-3 and MMP-9 expression were statistically significantly higher in patients with tumorous vascular\/lymphatic invasion, me\ntastases\nin regional lymph nodes, distant metastases and invasion into the spermatic cord (except of lightness of MMP-3 expression) in comparison with patients\nwithout these characteristics.\nConclusions: MMP-1, MMP-3 and MMP-9 are involved in carcinogenesis already at the early stages of embryonal carcinoma and at the transition to late stages\nthere is an increase of their synthesis, what proves their significant role in the destruction of extracellular matrix, invasion and metastatic process. Studied\nMMPs can be regarded as a prognostic factors of the embryonal carcinoma course as well as a potentially important therapeutic targets<\/jats:p>","DOI":"10.36740\/wlek\/208993","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T09:59:06Z","timestamp":1756115946000},"page":"1335-1341","source":"Crossref","is-referenced-by-count":0,"title":["State of extracellular matrix in testicular embryonal carcinoma"],"prefix":"10.36740","author":[{"given":"Serhii M.","family":"Potapov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr D.","family":"Markovskyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliia I.","family":"Horhol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena V.","family":"Kykhtenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olha V.","family":"Naumova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana M.","family":"Pliten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana V.","family":"Kaluzhyna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025,7,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-208993-128063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-208993-128063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T09:59:11Z","timestamp":1756115951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/State-of-extracellular-matrix-in-testicular-embryonal-carcinoma,208993,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025]]}},"alternative-id":["208993"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/208993","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]}}}