{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:59:36Z","timestamp":1792004376657,"version":"4.4.0"},"reference-count":0,"publisher":"ALUNA","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: Aim this study was to estimate the prevalence and incidence of HAI in patients with combat wounds, and determine phenotypic and genotypic aspects\nof antimicrobial resistance of the responsible pathogens in Ukraine.\nMaterials and Methods: A multicenter observational cohort study based on HAIs and antimicrobial resistance surveillance data in Ukraine. Between June\n21, 2022 and December 31, 2024, patients (aged 20-74 years) with combat wounds were admitted to civilian hospitals which are located in Kharkiv, Dnipro,\nKherson, Zaporizhzhia, Odessa, and Kyiv, Ukraine. The criteria for HAIs were adapted from the CDC\/NHSN. Antimicrobial susceptibility test used Kirby \u2013 Bauer\ndisc diffusion antibiotic test according to the EUCAST.\nResults: Among 7,324 patients with combat wound, 5,022 (68.6%) HAIs were observed. The most frequently reported HAI types were surgical site infections\n(27.3%), bone and joint infections (25.6%), skin and soft tissue infections (15.7%), bloodstream infections (9.7%), central nervous system infections (7.9%),\nand pneumonia (5.3%). In total, 88.9% isolates from patients with combat wounds were found to be MDROs. A significant number of the MDROs isolated\nfrom patients with HAIs had \u00df-lactamase genes, including extended-spectrum \u00df-lactamase (ESBL) (53.1%), OXA-type (32.9%), AmpC-type (35.7%), KPC-type\n(31.8%), and metallo-\u00df-lactamases (51.4%) including IMP-type (18.5%), VIM-type (29.6%), and NDM-1 (34.7%).\nConclusions: This study found a high prevalence of HAI in patients with combat wounds caused by MDROs, varying depending on the bacterial species, and\nantimicrobial group. The majority of MDRO isolates from patients with HAI carried \u00df-lactamase genes.<\/jats:p>","DOI":"10.36740\/wlek\/209517","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T18:13:10Z","timestamp":1758996790000},"page":"1624-1634","source":"Crossref","is-referenced-by-count":14,"title":["Healthcare associated infections in patients with combat wounds and antimicrobial resistance of the responsible pathogens in Ukraine: results of a multicenter study (2022-2024)"],"prefix":"10.36740","author":[{"given":"Aidyn G.","family":"Salmanov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro V.","family":"Shchehlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Mamonova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevhenii E.","family":"Shcheholkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor I.","family":"Litus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr V.","family":"Burakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor V.","family":"Altman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr P","family":"Kovalenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslav E.","family":"Kudelskyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleh E.","family":"Svyrydiuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykhailo V.","family":"Knyhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor A.","family":"Yatsyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihor M.","family":"Bortnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia O.","family":"Serohina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor V.","family":"Verbitskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenii A.","family":"Koichev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Brodskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2025,8,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-209517-129157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-209517-129157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T18:13:15Z","timestamp":1758996795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Healthcare-associated-infections-in-patients-with-combat-wounds-and-antimicrobial,209517,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025]]}},"alternative-id":["209517"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/209517","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,30]]}}}