{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:13:19Z","timestamp":1792462399084,"version":"4.5.0"},"reference-count":0,"publisher":"ALUNA","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the significance of growth factors (TGF-\u03b21 and CTGF) in the development and progression of diabetic retinopathy (DR) in carriers of different genotypes of the TGFB1 rs1800470 polymorphism in type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>A study examined 102 individuals with T2DM and DR, divided into three groups: non-proliferative DR (35), preproliferative DR (34), and proliferative DR (33), with 61 as controls. Standard ophthalmological exams and enzyme-linked immunosorbent assays were conducted. Alleles rs1800470 were determined using polymerase chain reaction. Statistical analyses were done using MedStat and MedCalc v.15.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results showed rs1800470 A\/A carriers had worse visual acuity and higher retinal thickness than G\/G carriers. TGF-\u03b21 and CTGF levels in DR patients were significantly higher than in controls, especially in G\/A and A\/A carriers. TGF-\u03b21 levels were highest in proliferative DR, and CTGF levels increased in A\/A carriers compared to G\/A and G\/G carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thus, the content of both TGF-\u03b21 and CTGF was higher in carriers of the G\/A and A\/A genotypes compared with the ancestral G\/G genotype. Therefore, the clinically worse course of DR in carriers of the SNP rs1800470 of the TGFB1 gene could be associated with a higher concentration of TGF-\u03b21 and CTGF in the IOF of such patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.36740\/wlek\/210020","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:12:29Z","timestamp":1765541549000},"page":"2088-2094","source":"Crossref","is-referenced-by-count":1,"title":["Possible role of the TGFB1 polymorphism rs1800470, transforming growth factor \u03b21 (TGF-\u03b21) and connective tissue growth factor (CTGF) in the progression of diabetic retinopathy in type 2 diabetes mellitus"],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0146-6367","authenticated-orcid":false,"given":"Andriy","family":"Hudz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1108-5707","authenticated-orcid":false,"given":"Ivan","family":"Kudryl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-7672","authenticated-orcid":false,"given":"Oksana","family":"Bushuieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0822-3638","authenticated-orcid":false,"given":"Sofiia","family":"Rafaliuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-3728","authenticated-orcid":false,"given":"Sergiy","family":"Ziablitsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2025,10,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-210020-133148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-210020-133148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:12:34Z","timestamp":1765541554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Possible-role-of-the-TGFB1-polymorphism-rs1800470-transforming-growth-factor-1-TGF,210020,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025]]}},"alternative-id":["210020"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/210020","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]}}}