{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:16:46Z","timestamp":1765541806051,"version":"3.48.0"},"reference-count":0,"publisher":"ALUNA","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To study and compare the efficacy of different regimens of combination antiviral therapy for hepatitis C and B in achieving a sustained virological response in patients with HIV\/HBV\/HCV coinfection and their impact on the degree of liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We examined 113 HIV-infected adult patients with HBV\/HCV coinfection who were registered at the Municipal Non-profit Enterprise \u201cInfectious Diseases Center of the Ivano-Frankivsk Regional Council\u201d between 2017 and 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The treatment regimens with two direct-acting antivirals (sofosbuvir\/ledipasvir, sofosbuvir+daclatasvir, sofosbuvir\/velpatasvir and sofosbuvir\/ledipasvir and ribavirin resulted in 100 % sustained virologic response. The efficacy of the pegylated interferon, sofosbuvir, and ribavirin regimen was lower, with sustained virologic response achieved in 86.2 % of patients. The lowest efficacy was observed with the sofosbuvir and ribavirin regimen \u2013 sustained virologic response achieved in 75.0 % of patients. Primary HBV resistance to tenofovir\/emtricitabine was identified in 1.76 % of patients in the entire cohort.  \nAmong patients in the group treated with combined antiviral therapy for HBV and HCV using tenofovir\/emtricitabine and direct-acting antivirals with or without ribavirin, the incidence of liver fibrosis F3-F4, as assessed by point-shear wave elastography, decreased from 20 % to 2.5 % (\u0440&lt;0,05) after one year of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with HIV\/HBV\/HCV coinfection, interferon-free regimens that include two direct-acting antivirals, either alone or in combination with ribavirin, demonstrated 100 % virologic efficacy and the most beneficial effects on the liver reducing the degree of liver fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.36740\/wlek\/210024","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:12:29Z","timestamp":1765541549000},"page":"2078-2087","source":"Crossref","is-referenced-by-count":0,"title":["Virological and Antifibrotic Efficacy of Antiviral Treatment for Hepatitis \u0412+C in HIV-positive Patients"],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5743-5481","authenticated-orcid":false,"given":"Mariana","family":"Prokopovych","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5131-0223","authenticated-orcid":false,"given":"Ihor","family":"Hryzhak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025,12,11]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-210024-133147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-210024-133147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:12:33Z","timestamp":1765541553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Virological-and-Antifibrotic-Efficacy-of-Antiviral-Treatment-for-Hepatitis-C-in-HIV,210024,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025]]}},"alternative-id":["210024"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/210024","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]}}}