{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:19:14Z","timestamp":1787030354512,"version":"build-2736575974"},"reference-count":0,"publisher":"ALUNA","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To determine the structural reorganization of the pancreas at late stages after experimental MSG exposure.\nMaterials and Methods: The study was performed on 20 sexually mature male rats. The experimental group received MSG orally at 70 mg\/kg of body\nweight daily for 8 weeks. The control group was fed a standard diet without MSG. Decapitation was performed at week 18. Pancreatic tissues were collected\nfor histological analysis and processed by standard methods.\nResults: Ten weeks after MSG withdrawal, atrophic areas were detected in the exocrine parenchyma. Acini and pancreatocytes decreased in size. In the ductal\nepithelium, dystrophic and destructive changes were observed, including cytoplasmic metachromasia, nuclear pyknosis, eccentric localization, and karyorrhexis.\nPeriductal sclerosis and pancreatic lipomatosis were recorded. Vascular walls were thickened and homogeneous due to edema and mucoid swelling. Capillaries\nwere plethoric with stasis and occasional perivascular hemorrhages.\nConclusions: At late stages after MSG exposure, marked alterations in pancreatic structure were revealed. Irreversible atrophic changes of exocrinocytes led\nto dysfunction of the gland, indicating the toxic effect of monosodium glutamate.<\/jats:p>","DOI":"10.36740\/wlek\/212378","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:38:02Z","timestamp":1761665882000},"page":"1725-1730","source":"Crossref","is-referenced-by-count":1,"title":["Microscopic changes in the pancreas at late stages after\nexperimental exposure to monosodium glutamate"],"prefix":"10.36740","author":[{"given":"Mykhailo Yu.","family":"Kochmar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliia V.","family":"Lytvak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr I.","family":"Hetsko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr M.","family":"Kochmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihor K.","family":"Kharkhalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olesya O.","family":"Valko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2025,9,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-212378-131733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-212378-131733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:38:03Z","timestamp":1761665883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Microscopic-changes-in-the-pancreas-at-late-stages-after-nexperimental-exposure-to,212378,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025]]}},"alternative-id":["212378"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/212378","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}