{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:46:20Z","timestamp":1761666380518,"version":"build-2065373602"},"reference-count":0,"publisher":"ALUNA","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To study the peculiarities of energy metabolism in full-term newborns with neonatal hyperbilirubinemia.\nMaterials and Methods: It was conducted the comprehensive examination of 30 full-term newborns with signs of neonatal jaundice (main group) and 30\nhealthy infants (control group).\nIt was determined the level of lactate, pyruvate and lactate\/pyruvate ratio in the blood serum; in the bloods lymphocytes \u2013 level of Glycerol-3-phosphate\nDehydrogenase (GPDH), Succinate Dehydrogenase (SDH), and Nicotinamide Adenine Dinucleotide Dehydrogenase (NADH-D), Aerobic Respiration Rate (AR)\nand Electronic Transport Chain coefficient (ETC).\nStatistical analysis of the results was conducted using STATISTICA (Version 10) software, MedCalc Software (Version 16.1).\nResults: Newborns of main group \u2013 in comparison to control group was defined: statistically significant lower lactate and pyruvate levels with statistically\nhigher lactate\/pyruvate ratio (53.62 \u00b1 6.49 and 29.02 \u00b1 9.87, p &lt; 0.0001 respectively); statistically significant lower GPDH, SDH and NADH-D activities;\nstatistically significant lower ETC coefficient (14.58 \u00b1 3.56 and 21.13 \u00b1 1.51 a.u., p &lt; 0.0001 respectively) with statistically significant higher AR coefficie\n(13.22 \u00b1 9.13 and 8.42 \u00b1 3.29 a.u., p = 0.0102 respectively).\nConclusions: Full-term newborns with signs of pathological hyperbilirubinemia have significant disruptions in the relationship between aerobic and anaerobic\nenergy processes in comparison to healthy infants. The higher discriminatory ability level was defined in diagnostic model using ETC coefficient (cut-off level\n\u2264 19.48, AUC 0.918; 95 % CI 0.841; 0.966, p &lt; 0.0001, sensitivity 92.45 %, specificity 91.67 %).<\/jats:p>","DOI":"10.36740\/wlek\/212384","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:38:02Z","timestamp":1761665882000},"page":"1718-1724","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of energy metabolism in full-term newborns\nwith neonatal hyperbilirubinemia"],"prefix":"10.36740","author":[{"given":"Yulia M.","family":"Volosivska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasiya G.","family":"Babintseva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliya D.","family":"Hodovanets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymdyr A.","family":"Petrov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya I.","family":"Kovtyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya O.","family":"Popeliuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana I.","family":"Yurkiv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2025,9,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-212384-131732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-212384-131732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:38:03Z","timestamp":1761665883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Characteristics-of-energy-metabolism-in-full-term-newborns-nwith-neonatal-hyperbilirubinemia,212384,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025]]}},"alternative-id":["212384"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/212384","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}