{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:59:03Z","timestamp":1788303543192,"version":"build-2803163510"},"reference-count":0,"publisher":"ALUNA","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: This review aims to analyze the microbiology, pathogenesis, and current therapeutic strategies of dental caries and periodontal diseases, with a focus on the role of polymicrobial biofilms, host\u2013microbe interactions, and the major pathogenic species involved in disease progression.\n\nMaterials and Methods:A comprehensive literature review was conducted using major scientific databases, including PubMed, Scopus, Web of Science, and Google Scholar. Studies published between 2000 and 2025 were included. Relevant experimental, clinical, and review articles addressing the etiology, microbial composition, virulence mechanisms, host immune responses, and therapeutic approaches for dental caries and periodontal disease were analyzed.\n\nResults:The oral cavity contains more than 700\u2013800 bacterial species, with Streptococcus mutans serving as the primary cariogenic pathogen and Porphyromonas gingivalis identified as a key driver of periodontal disease. Dental caries progression is primarily attributed to acid production and enamel demineralization, while periodontal disease results from a dysbiotic shift in the subgingival microbiome accompanied by destructive host inflammatory responses. The \u201cred complex\u201d (P. gingivalis, Treponema denticola, and Tannerella forsythia) exhibits strong synergistic virulence in advanced periodontitis. Biofilm formation, extracellular polysaccharide (EPS) matrix production, quorum sensing, and immune components such as neutrophils, macrophages, and matrix metalloproteinases (MMPs) all contribute to disease development\n\nConclusions:Dental caries and periodontal diseases result from complex interactions between polymicrobial biofilms and host immune responses. A deeper understanding of microbial ecology, virulence pathways, and host\u2013pathogen interactions is essential for improving prevention and treatment. Advances in targeted antimicrobial therapies and innovative therapeutic approaches hold promise for enhancing global oral health outcomes.<\/jats:p>","DOI":"10.36740\/wlek\/216932","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:57:37Z","timestamp":1779101857000},"page":"829-846","source":"Crossref","is-referenced-by-count":1,"title":["Microbiology of Dental Decay and Periodontal Disease: A Review"],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4341-536X","authenticated-orcid":false,"given":"Hebatallah Mohammed","family":"Khudhair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-5937","authenticated-orcid":false,"given":"Ali Saud Hadi","family":"Alhamdani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0764-7533","authenticated-orcid":false,"given":"Ahmed Mahdi Hasan","family":"Al -Tameemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,4,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-216932-140176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-216932-140176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T12:15:07Z","timestamp":1779711307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Microbiology-of-Dental-Decay-and-Periodontal-Disease-A-Review,216932,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"alternative-id":["216932"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/216932","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}