{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:45:41Z","timestamp":1772822741218,"version":"3.50.1"},"reference-count":0,"publisher":"ALUNA","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To investigate the physicochemical properties and antibacterial and antibiofilm activity of nanocomposites Ag\/Cu2O synthesized by the polyol method.\n\nMaterials and Methods: The nanocomposites Ag\/Cu2O were synthesized using the polyol method, followed by a study of their physicochemical properties. The\n\nantibacterial and antibiofilm properties of the nanocomposites Ag\/Cu2O were investigated against multidrug-resistant clinical strains of bacteria S. aureus, E.\n\ncoli, and P. aeruginosa.\nResults: Nanocomposites Ag\/Cu2O, were mostly spherical in shape and had an average size of 135.6\u00b165 nm. X-ray diffraction analysis confirmed the presence\n\nof Ag and Ag\/Cu2O phases. Energy-dispersive spectroscopy revealed the following elemental composition: 13.05% silver, 31.81% copper, and 55.14% oxygen.\nu2\nUltraviolet-visible spectroscopy suggested the potential presence of silver oxides in the structure. The minimum inhibitory concentration and minimum bac\ntericidal\nconcentration values were as follows: for S. aureus, the minimum inhibitory concentration was 52.08\u00b118.04 \u00b5g\/ml, and the minimum bactericidal\nconcentration \u2013 72.92\u00b147.74 \u00b5g\/ml; for P. aeruginosa \u2013 26.04\u00b19.02 \u00b5g\/ml, and 41.67\u00b118.04 \u00b5g\/ml, respectively; and for E. coli \u2013 83.33\u00b136.08 \u00b5g\/ml, and\n208.30\u00b172.17 \u00b5g\/ml, respectively. The nanocomposites Ag\/Cu2O NCs also demonstrated antibiofilm activity, being effective against S. aureus at 3 and 5 times\nu2\nthe minimum bactericidal concentration, against E. coli at 1, 3, and 5 times the minimum bactericidal concentration, and against P. aeruginosa at 5 times the\nminimum bactericidal concentration.\nConclusions: The nanocomposites Ag\/Cu2O revealed high antibacterial and antibiofilm properties, which support their use as an alternative to conventional\nu2\nantibiotics in nanomedicine for treating multidrug-resistant infections.<\/jats:p>","DOI":"10.36740\/wlek\/217263","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:08:07Z","timestamp":1772802487000},"page":"9-14","source":"Crossref","is-referenced-by-count":0,"title":["Ag\/Cu\u2082O nanocomposites as an alternative antimicrobial agent for multidrug-resistant bacterial infections"],"prefix":"10.36740","author":[{"given":"Igor","family":"Duzhyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petro","family":"Myronov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetiana","family":"Ivakhniuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Pshenychnyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr","family":"Pylypenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatolii","family":"Opanasyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoriia","family":"Holubnycha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladyslav","family":"Smiianov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2026,1,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-217263-136034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-217263-136034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:08:08Z","timestamp":1772802488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Ag-Cu-O-nanocomposites-as-an-alternative-antimicrobial-agent-for-multidrug-resistant,217263,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"alternative-id":["217263"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/217263","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]}}}