{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:58:48Z","timestamp":1775732328855,"version":"3.50.1"},"reference-count":0,"publisher":"ALUNA","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Background: Renal cell carcinoma represents the most common type of kidney cancer with critical role of DNA repair mechanisms in carcinogenesis.\nAims: investigate the association RAD18 Arg302Gln (rs373572) and OGG1 Ser326Cys (rs1052133) - with RCC susceptibility and histopathological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Methodology: A case\u2013control study was conducted using allele-specific PCR for genotyping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results: The cohort comprised cases with clear cell, chromophobe, and variant RCC subtypes. A significant link was found between OGG1 rs1052133 and RCC risk (p = 0.006), with the GG genotype being strongly linked to disease occurrence p=0.005. Haplotype analysis identified a significant association of the GC with RCC (p=0.013). LD analysis revealed a significant interaction between RAD18 and OGG1 loci (\u03c7\u00b2 = 9.214, p = 0.027), with an r- value of 0 in cases and 0.14 in controls. Histopathological correlations revealed that OGG1 rs1052133 genotypes showed a highly significant association with RCC p&lt;0.001. RAD18 rs373572 genotypes were significantly closed link with tumor stage p=0.001. TNM classification exhibited a significant correlation with RAD18 genotypes p=0.017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Conclusion: A significant association between OGG1 rs1052133 and both RCC susceptibility and tumor histological subtype, proposed a potential role in disease pathogenesis. RAD18 rs373572 showed relevance to tumor stage and TNM classification, indicating a possible role in disease progression rather than initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.36740\/wlek\/217773","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:05:21Z","timestamp":1775729121000},"page":"317-327","source":"Crossref","is-referenced-by-count":0,"title":["DNA repair RAD 18 rs373572 and OGG1 rs1052133 genes polymorphisms association with Histological Characterization of Renal Cell Carcinoma"],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2018-1951","authenticated-orcid":false,"given":"Iftikhar Khdhair Abbas","family":"Altemimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0694-0771","authenticated-orcid":false,"given":"Binan Adil Mohammed","family":"Ameen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9244-6709","authenticated-orcid":false,"given":"Mona N.","family":"Al-Terehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-2419","authenticated-orcid":false,"given":"Liwaa Mahdi","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2026,2,27]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-217773-138339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-217773-138339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:05:24Z","timestamp":1775729124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/DNA-repair-RAD-18-rs373572-and-OGG1-rs1052133-genes-polymorphisms-association-with,217773,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"alternative-id":["217773"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/217773","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}