{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:58:48Z","timestamp":1775732328697,"version":"3.50.1"},"reference-count":0,"publisher":"ALUNA","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To evaluate E-cadherin expression in various clinical and pathological prognostic scenarios to determine its significance in the development of molecular\nsubtypes of invasive ductal breast cancer.\nMaterials and Methods: A comprehensive morphological and immunohistochemical study of 80 cases of invasive ductal carcinoma (IDC) was conducted\nto determine the molecular phenotype. The expression of E-cadherin, ER, PR receptors, c-erbB2, and Ki-67 was evaluated according to the manufacturer\u2019s\nstandardized protocols using appropriate positive and negative controls. The degree of tumor malignancy was determined using the modified Scarff-Bloom-\nRichardson system. Semi-quantitative assessment of E-cadherin expression was performed using the Qureshi scale. Pearson\u2019s criterion was used for statistical\nanalysis. Differences were considered statistically significant at p &lt; 0.05.\nResults: Low E-cadherin expression was associated with stage 3, pT3, and G2\/G3 grades of IDBC malignancy, confirming its unfavorable prognostic significanc\nand correlation with the molecular profile. High E-cadherin expression was characteristic of ER-positive luminal A tumors, regardless of menopause, indicating\na regulatory role for ER expression. The low proliferative activity of luminal IDBC cells was explained by high E-cadherin expression, which increased adhesive\nproperties. Low E-cadherin expression is also a prognostic marker for TNBC.\nConclusions: E-cadherin is a potent tumor suppressor in breast cancer. Its role in disease progression is confirmed by the correlation between partial or complete\nloss of E-cadherin expression and poor prognosis for patients.<\/jats:p>","DOI":"10.36740\/wlek\/218713","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:05:21Z","timestamp":1775729121000},"page":"255-264","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of \u0415-cadherin expression in invasive ductal breast cancer"],"prefix":"10.36740","author":[{"given":"Ilona V.","family":"Chelpanova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliya I.","family":"Volos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrii P.","family":"Dudash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yevgen V.","family":"Paltov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur V.","family":"Poliiants","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olha V.","family":"Dudok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia V.","family":"Hnidyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2026,2,27]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-218713-138324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-218713-138324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:05:22Z","timestamp":1775729122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Evaluation-of-cadherin-expression-in-invasive-ductal-breast-cancer,218713,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"alternative-id":["218713"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/218713","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}