{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:06:52Z","timestamp":1789553212975,"version":"build-2803163510"},"reference-count":0,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify clinically significant diagnostic criteria for oligosymptomatic choledocholithiasis and determine their diagnostic value in patients with acute calculous cholecystitis (ACC) based on instrumental and laboratory examination data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>The study included 129 patients divided into two groups: the study group (I) and the comparison group (II). The study group included patients with ACC and oligosymptomatic choledocholithiasis (n=83), while the comparison group included patients with ACC without OCL (n=46).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A univariate analysis using logistic regression identified nine factors with prognostic value for determining the presence of OCL. A high quality of OCL prediction was observed (AUC=0.99). The optimal decision threshold for diagnosing OCL was 0.5. Sensitivity at the established threshold was 100%, specificity was 88.90%, and accuracy was 96.88% (p&lt;0.001). a multivariate regression model based on six factors was developed to enhance the clinical applicability of OCL prediction in ACC. This model also demonstrated a high predictive quality (AUC=0.98) compared to the nine-factor model. The decision threshold for the presence or absence of OCL was 0.6. The sensitivity of this model was 95.65%, specificity was 88.90%, and accuracy was 93.75%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The diameter of the common bile duct, the activity of ALT, AST, alkaline phosphatase, total bilirubin levels, as well as the expression levels of miR-122 and miR-21 in serum and bile, serve as reliable diagnostic criteria associated with the presence of oligosymptomatic choledocholithiasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.36740\/wlek\/218750","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:33Z","timestamp":1789551573000},"page":"1606-1614","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic criteria for oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis"],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-6159","authenticated-orcid":false,"given":"Oleg","family":"Terletskyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0646-6306","authenticated-orcid":false,"given":"Vasyl I","family":"Kolomiytsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4814-0964","authenticated-orcid":false,"given":"Mariya M.","family":"Bufan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0863-4046","authenticated-orcid":false,"given":"Halyna V.","family":"Kurylo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-218750-145229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-218750-145229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:40Z","timestamp":1789551580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Diagnostic-criteria-for-oligosymptomatic-choledocholithiasis-in-patients-with-acute,218750,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"alternative-id":["218750"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/218750","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}