{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:10:36Z","timestamp":1778839836454,"version":"3.51.4"},"reference-count":0,"publisher":"ALUNA","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To summarize current approaches to diagnosing and evaluating clinical features and disease course of Crohn\u2019s disease, and to provide competency-based\npractical recommendations for diagnostic assessment in children with early-onset disease.\nMaterials and Methods: Literature analysis was conducted using electronic databases (PubMed, Medline, the Cochrane Library) and the author\u2019s clinical\ncases of Crohn\u2019s disease in 7 children aged 1 year 10 months to 4.5 years. The diagnostic algorithm in young children included general clinical examination\nand laboratory and instrumental methods, including genetic testing and serological markers. Morphological verification of the diagnosis by histological\nexamination of biopsy specimens is mandatory.\nConclusions: Delayed diagnosis of Crohn\u2019s disease in young children results from nonspecific symptoms, variable early manifestations, and prominent\nextraintestinal features. Early-onset disease poses a major diagnostic challenge and requires increased awareness of extraintestinal manifestations, perianal\nlesions, and growth failure. Serological tests serve as supportive tools and do not exclude the diagnosis when negative, particularly in children under 6 years.\nGenetic screening to rule out primary immunodeficiencies is an essential part of the diagnostic workup in this age group.<\/jats:p>","DOI":"10.36740\/wlek\/219918","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:30:53Z","timestamp":1778837453000},"page":"817-821","source":"Crossref","is-referenced-by-count":0,"title":["Complex diagnostic approach in early manifestation of crohn\u2019s disease in children"],"prefix":"10.36740","author":[{"given":"Olga M.","family":"Gorbatyuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2026,4,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-219918-139971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-219918-139971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:30:57Z","timestamp":1778837457000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Complex-diagnostic-approach-in-early-manifestation-of-crohn-s-disease-in-children,219918,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"alternative-id":["219918"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/219918","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}