{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T19:45:24Z","timestamp":1782675924326,"version":"3.54.5"},"reference-count":0,"publisher":"ALUNA","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Aim: To study the effectiveness of ursodeoxycholic acid use in the combined treatment of intestinal dysbiosis in patients with chronic Hepatitis C associated\nwith obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>84 patients with CHC were examined. All patients underwent a microbiological study of stool, the levels of cytokine profile indicators\nwere determined and the psychological status and the quality of life were assessed. Two groups were formed: 1 gr (n=40) \u2013 received LA-5 and BB-12 1 gtt. x\nTID and 2 gr (n=44) - LA-5 + BB-12 + UDCA 500 mg qhs for 1 month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As a result of simultaneous administration of LA-5 + BB-12 + UDCA in the above-mentioned doses, in 93.2% of patients with CHC an normalization\nof the act of defecation and the disappearance of symptoms of intestinal dysbiosis were found. In patients taking only LA-5 and BB-12, the above-mentioned\npositive changes were observed in 62.5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It was found that the additional prescription of UDCA in combination with a probiotic not only contributes to the restoration of colon microbiocenosis,\nbut also improves the course of CH\u0421, and increases the quality of life of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.36740\/wlek\/220828","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T19:30:14Z","timestamp":1782675014000},"page":"936-944","source":"Crossref","is-referenced-by-count":0,"title":["Combined treatment of intestinal dysbiosis in patients with chronic hepatitis c on the background of obesity"],"prefix":"10.36740","author":[{"given":"Mariya A.","family":"Derbak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vira V.","family":"Vorobets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevheniia E.","family":"Dankanych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrii D.","family":"Sitkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olesya M.","family":"Horlenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatolija A.","family":"Krasnova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myroslava M.","family":"Bletskan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,5,29]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-220828-141688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-220828-141688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T19:30:16Z","timestamp":1782675016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Combined-treatment-of-intestinal-dysbiosis-in-patients-with-chronic-hepatitis-c-on,220828,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"alternative-id":["220828"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/220828","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}