{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:06:53Z","timestamp":1789553213004,"version":"build-2803163510"},"reference-count":0,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate and compare the levels of the beta-subunit of NGF (Beta-NGF) and middle molecular mass molecules (MMM) in the blood of patients with post-traumatic non-firearm and firearm neuropathies and plexopathies accompanied by chronic neuropathic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We examined 93 men aged 21-59 years with compression-ischemic (groupI - comparison), post-traumatic non-firearm (groupII) and firearm (groupIII) neuropathies and plexopathies with and without chronic neuropathic pain syndrome. Quantitative determination of \u0412\u0435t\u0430-NGF in serum was performed by enzyme-linked immunosorbent assay. The content of MMM was determined by spectrophotometric method (fractions MMM238, MMM254, MMM260, MMM280). The following integral indices were calculated: peptide-nucleotide ratio, distribution coefficient, aromaticity coefficient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We revealed an increased level of Beta-NGF in the blood serum of patients with post-traumatic firearm and non-firearm neuropathies and plexopathies accompanied by chronic neuropathic pain (Mann-WhitneyU-test,p=0.0077 and Mann-WhitneyU-test,p=0.04608, respectively). The level of the CR280\/254 in patients of groupIII with post-traumatic firearm neuropathies and plexopathies at a statistically significant level depends on the presence of chronic neuropathic pain (Mann-WhitneyU-test,p=0.0113). The accumulation of biologically active molecules involved in the activation of compensatory, protective mechanisms in patients with post-traumatic firearm neuropathies and plexopathies accompanied by chronic neuropathic pain was established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results confirm the existing data on the pathophysiological role of Beta-NGF and MMM in the development of chronic neuropathic pain and indicate the potential use of NGF as a therapeutic target, while the CR280\/254 ratio may serve as a biomarker reflecting the accumulation of biologically active molecules associated with chronic neuropathic pain in patients with post-traumatic neuropathies and plexopathies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.36740\/wlek\/222252","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:33Z","timestamp":1789551573000},"page":"1591-1597","source":"Crossref","is-referenced-by-count":0,"title":["Changes in the levels of nerve growth factor and middle molecular mass molecules in patients with post-traumatic neuropathies and plexopathies accompanied by chronic neuropathic pain"],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4647-8507","authenticated-orcid":false,"given":"Tetyana Anatoliivna","family":"Litovchenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-6157","authenticated-orcid":false,"given":"Olena","family":"Borodai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-1335","authenticated-orcid":false,"given":"Oksana Borysivna","family":"Bondar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4120-3280","authenticated-orcid":false,"given":"Anna","family":"Voitiuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2157-0181","authenticated-orcid":false,"given":"Vartanush","family":"Florikian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-168X","authenticated-orcid":false,"given":"Olena","family":"Zavalna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-6980","authenticated-orcid":false,"given":"Viktor","family":"Lytovchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-222252-145227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-222252-145227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:39Z","timestamp":1789551579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Changes-in-the-levels-of-nerve-growth-factor-and-middle-molecular-mass-molecules,222252,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"alternative-id":["222252"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/222252","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}