{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:06:52Z","timestamp":1789553212015,"version":"build-2803163510"},"reference-count":0,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Background: Venous thrombosis is a major clinical concern, yet experimental models that closely replicate human thrombus formation are limited.\nAims: This study aimed to establish a novel rabbit model using direct electrical stimulation to induce internal jugular vein injury and subsequent organ-specific thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Methods: Twenty-one male New Zealand White rabbits underwent jugular vein thrombosis induction via direct current (DC) electrical stimulation. D-Dimer assays confirmed thrombus formation. Histopathological analyses of the lungs, heart, and brain assessed thromboembolic changes. Thrombosis induction was tested at varying DC voltages and exposure durations: 6 V for 60 s, 12 V for 120 s, and 24 V for 180 s.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results: In the lungs (6 V\/60 s), thrombi exhibited characteristic lines of Zahn with dense platelet and fibrin deposition, alveolar wall destruction, emphysematous changes, and wedge-shaped hemorrhagic pulmonary infarctions. In the heart (12 V\/120 s), thrombus formation was observed in coronary arteries, with interstitial hemorrhage and altered cardiac muscle fibers showing rounded and oval nuclei. In the brain (24 V\/180 s), acute neuronal injury was evident, including shrunken eosinophilic \u201cred neurons,\u201d cerebral edema, liquefactive necrosis, small-vessel hemorrhage, and astrocyte proliferation. These findings indicate voltage- and duration-dependent induction of thromboembolism with organ-specific distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Conclusions: Direct DC electrical stimulation induces deep vein thrombosis in rabbits in a voltage- and duration-dependent manner. Lower voltage and shorter exposure primarily affect the lungs, moderate settings target the heart, and higher voltage with longer duration affect the brain. This model provides a controlled platform for studying organ-specific thromboembolism and evaluating therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.36740\/wlek\/222507","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:33Z","timestamp":1789551573000},"page":"1549-1555","source":"Crossref","is-referenced-by-count":0,"title":["&lt;i&gt;In vivo&lt;\/i&gt; induction of different venous thromboembolism by use of DC electrical shock on jugular vein endothelium"],"prefix":"10.36740","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-0070","authenticated-orcid":false,"given":"Hanady M.","family":"Moker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8002-5100","authenticated-orcid":false,"given":"Esraa A.","family":"Qoryi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-2542","authenticated-orcid":false,"given":"Rafid","family":"Doulab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-222507-145217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-222507-145217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:37Z","timestamp":1789551577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/-In-vivo-induction-of-different-venous-thromboembolism-by-use-of-DC-electrical-shock,222507,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"alternative-id":["222507"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/222507","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}