{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:13:34Z","timestamp":1785521614251,"version":"3.56.0"},"reference-count":0,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the clinical significance of serum L-selectin (sCD62L) levels as a biomarker of retinal damage in patients with type 2 diabetes mellitus (T2DM)\nby correlating its concentration with the stages of diabetic retinopathy (DR) and clinical and morphological parameters of the retinal state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A total of 124 patients (124 eyes) were examined: 95 patients with T2DM (ranging from mild non-proliferative to proliferative DR) and\n29 age- and sex-matched controls. Diagnostic techniques included BCVA assessment, SD-OCT (Topcon 3D OCT-1000), and serum ELISA for L-selectin determination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant 2.5-fold increase in serum L-selectin levels was identified in the T2DM cohort compared to controls ([mean \u00b1 standard error] 31.2 \u00b1\n8.6 ng\/mL vs. 12.5 \u00b1 3.5 ng\/mL; p &lt; 0.001). A progressive upward trend in marker concentration was observed relative to pathology severity: from (median\n[interquartile range]) 24.7 (20.4\u201329.0) ng\/mL in mild non-proliferative DR (p &lt; 0.001 vs. control group [12.5 (10.1\u201314.9)] ng\/mL) to 39.5 (35.1\u201343.9) ng\/\nmL in the proliferative stage (p &lt; 0.001 vs. control group). Positive correlations were found between L-selectin levels and HbA1c (rs = 0.816, p &lt; 0.001), as\nwell as central retinal thickness (rs = 0.467, p = 0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CD62L is a significant biomarker of systemic inflammation and vascular dysfunction in T2DM, reflecting the severity of diabetic retinopathy and\nthe risk of blood-retinal barrier disruption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.36740\/wlek\/222590","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:04:17Z","timestamp":1785517457000},"page":"1188-1193","source":"Crossref","is-referenced-by-count":0,"title":["L-selectin as a systemic biomarker of retinal damage in type 2 diabetes"],"prefix":"10.36740","author":[{"given":"Sergiy O.","family":"Rykov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna V.","family":"Shargorodska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurii V.","family":"Barinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro \u0406.","family":"Chuhaiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olha S.","family":"Sas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia N.","family":"Aleieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizhan","family":"Magazova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,6,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-222590-142974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-222590-142974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:04:19Z","timestamp":1785517459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/L-selectin-as-a-systemic-biomarker-of-retinal-damage-in-type-2-diabetes,222590,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"alternative-id":["222590"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/222590","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}