{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:06:52Z","timestamp":1789553212786,"version":"build-2803163510"},"reference-count":0,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: The aim of this study is to analyze current data on the molecular and cellular mechanisms underlying the development of degenerative-dystrophic\ndiseases of the temporomandibular joint (TMJ). The article explores the potential of collagen therapy as a pathogenetically substantiated approach to the\ncomprehensive treatment of this disease.\nMaterials and Methods: A systematic review of the scientific literature over the past 20 years was conducted, indexed in PubMed\/MEDLINE, Scopus, Web of\nScience, the Cochrane Library, RCSB Protein Data Bank until March 2026.\nA comprehensive literature search identified 14,865 publications. Following a sequential analysis of titles, abstracts, and full texts based on predefined\ninclusion criteria (original experimental and clinical studies, systematic reviews and meta-analyses that revealed the molecular and cellular mechanisms of\nTMJ osteoarthritis, the therapeutic impact of types I and II collagen on joint and bone regeneration) and exclusion criteria (irrelevant papers, duplicates, TMJ\nrheumatoid arthritis, septic arthritis, systemic vasculitis). Ultimately, 37 primary sources were selected for the final review.\nConclusions: The authors summarized current data on the pathogenetic mechanisms of TMJ osteoarthritis, analyzed data on the use of collagen in the treatment\nof TMJ. The biological role of collagen types I and II as key structural components of fibrocartilage and subchondral bone is examined.\nSpecial attention is given to the feasibility of using injectable tropocolagen to stimulate reparative processes in the TMJ.<\/jats:p>","DOI":"10.36740\/wlek\/225981","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:33Z","timestamp":1789551573000},"page":"1654-1660","source":"Crossref","is-referenced-by-count":0,"title":["The role of collagen types I and II in the regeneration of temporomandibular joint and bone tissues: from molecular mechanisms to modern treatment protocols: Literature review"],"prefix":"10.36740","author":[{"given":"Oksana S.","family":"Volovar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana O.","family":"Kryzhanivska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergii M.","family":"Binetskyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volodymyr S.","family":"Shvydchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-225981-145234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-225981-145234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:42Z","timestamp":1789551582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/The-role-of-collagen-types-I-and-II-in-the-regeneration-of-temporomandibular-joint,225981,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"alternative-id":["225981"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/225981","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}