{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:06:52Z","timestamp":1789553212103,"version":"build-2803163510"},"reference-count":0,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To establish the features of morphofunctional organization of the rat urinary bladder in modeled hyperglycemia, taking into account the complex of\nstructural-metabolic changes in the organism in the dynamics of its development.\nMaterials and Methods: The work was performed in compliance with the rules of humane treatment in experiments on 80 one-year-old male Wistar rats.\nStreptozotocin diabetes was modeled in 50 animals by single intraperitoneal administration of streptozotocin with material collection on days 14, 28, 42,\n56, and 70 of the experiment. Histological, electron microscopic, biochemical, massometric methods, measurement of consumed water and daily diuresis,\nmorphometric methods, cluster analysis, and statistical methods were applied.\nResults: Urothelial cells form four clusters with histometric and ultrastructural characteristics. Chronological features of streptozotocin diabetes development\nwere confirmed by blood glucose level, glycosylated hemoglobin content, urine glucose concentration, its pH, massometric indicators of body weight and\nurinary bladder weight, and volumes of consumed liquid and diuresis. Disruption of structural-functional balance between urothelial cell clusters is detected\nfrom day 14 until the end of the experiment. On days 14-28 of streptozotocin diabetes development, compensatory hypertrophy of smooth myocytes of the\nbladder wall with ultrastructural signs of their functional stress was detected, as well as the first signs of diabetic microangiopathy in the bladder wall. From\nday 56, generalization of sludge syndrome, dystrophic changes in endotheliocytes, and basement membrane edema are observed. Against the background of\npronounced microangiopathy, diuresis and polydipsia decrease, desquamation of urothelial cells intensifies, and dehydration of smooth myocytes and urothelial\ncells occurs, which is pronounced on day 70 of the experiment.\nConclusions: In the dynamics of induced hyperglycemia development, disruption of structural-functional balance between urothelial cell clusters was detected,\nleading to imbalance between proliferative potentials of basal urothelial cells and integrity of the urothelial cellular barrier, as well as stages of differentiation\nof intermediate urothelial cells. Diabetic microangiopathy intensifies until day 70 of the experiment. Overall, during this period, diabetic cystopathy remains\ncompensated (percentage of smooth myocyte area is 1.16 times greater than control and percentage of collagen fiber area is 1.23 times less than control).<\/jats:p>","DOI":"10.36740\/wlek\/225987","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:33Z","timestamp":1789551573000},"page":"1556-1562","source":"Crossref","is-referenced-by-count":0,"title":["Features of structural organization of the urinary bladder\nunder conditions of experimentally modeled hyperglycemia"],"prefix":"10.36740","author":[{"given":"Nadiya S.","family":"Tokaruk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrii O.","family":"Yurakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana H.","family":"Popadynets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliia V.","family":"Sobol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykhailo B.","family":"Pastukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larysa Ya.","family":"Fedoniuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-225987-145218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-225987-145218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:38Z","timestamp":1789551578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Features-of-structural-organization-of-the-urinary-bladder-nunder-conditions-of-experimentally,225987,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"alternative-id":["225987"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/225987","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}