{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:06:53Z","timestamp":1789553213436,"version":"build-2803163510"},"reference-count":0,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the leading cause of dementia and remains a major global health challenge. Although current disease-modifying therapies primarily\ntarget amyloid-\u03b2 and tau pathology, their clinical efficacy is limited. Increasing evidence indicates that AD is a multifactorial disorder involving neuroinflammation,\nmitochondrial dysfunction, impaired autophagy-lysosomal pathways, and dysregulated lipid metabolism. These interconnected mechanisms contribute\nto disease progression and represent promising therapeutic targets. This narrative review summarizes current evidence on emerging treatment strategies\nbeyond the classical amyloid and tau paradigm, with particular emphasis on microglial activation, mitochondrial function, autophagy, and lipid homeostasis.\nAdditionally, the translational potential of lifestyle-based interventions, including physical activity and metabolic regulation, is discussed. A broader understanding\nof AD pathogenesis may support the development of integrated therapeutic approaches combining pharmacological and non-pharmacological\nstrategies to improve clinical outcomes.<\/jats:p>","DOI":"10.36740\/wlek\/226612","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:33Z","timestamp":1789551573000},"page":"1685-1691","source":"Crossref","is-referenced-by-count":0,"title":["Emerging therapeutic targets beyond amyloid and tau in\nAlzheimer\u2019s Disease: Implications for lifestyle, metabolism and\npreventive medicine"],"prefix":"10.36740","author":[{"given":"Nataliya","family":"Izhytska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katazyna Anna","family":"Sobczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina Wiktoria","family":"Ogrodnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mazurkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Malentowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Julia","family":"Szafraniec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Bro\u017cyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u0142omiej","family":"Sa\u0142apski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalina","family":"Pastuszka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-226612-145238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-226612-145238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:43Z","timestamp":1789551583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/Emerging-therapeutic-targets-beyond-amyloid-and-tau-in-nAlzheimer-s-Disease-Implications,226612,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"alternative-id":["226612"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/226612","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}