{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:06:52Z","timestamp":1789553212993,"version":"build-2803163510"},"reference-count":0,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiadomo\u015bci Lekarskie"],"abstract":"<jats:p>Aim: To analyse the role of polymorphic sites in genes encoding key regulators of the hypothalamic-pituitary-adrenal axis and the neurotrophic system, which\nplay an important role in determining genetic susceptibility to the development of post-traumatic stress disorder.\nMaterials and Methods: To prepare this review, a systematic search was conducted in the Scopus, PubMed and ResearchGate databases using keywords\nrelating to the genetic aspects of PTSD development. The analysis included publications from the last ten years that examined molecular-genetic mechanisms,\nthe role of polymorphisms in shaping individual vulnerability to stress, and their impact on the regulation of the hormonal response.\nConclusions: Genetic variability is an important factor determining individual differences in susceptibility to PTSD. Studying polymorphisms in investigated\ngenes helps to explain the difference between resilience and susceptibility to mental disorders following traumatic events. This will help to improve the development\nof personalised approaches to the diagnosis, prognosis and treatment of PTSD, and opens up prospects for the creation of new therapeutic strategies\nthat take into account patients\u2019 individual genetic characteristics.<\/jats:p>","DOI":"10.36740\/wlek\/231365","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:33Z","timestamp":1789551573000},"page":"1692-1699","source":"Crossref","is-referenced-by-count":0,"title":["The role of genetic predictors in PTSD development"],"prefix":"10.36740","author":[{"given":"Vladyslav \u0410.","family":"Smiianov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriia Yu.","family":"Harbuzova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana B.","family":"Oleshko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olha A.","family":"Obukhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia O.","family":"Dryha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr \u041c.","family":"Oleshko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"link":[{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-231365-145239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/pdf-231365-145239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:39:43Z","timestamp":1789551583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wiadomoscilekarskie.pl\/The-role-of-genetic-predictors-in-PTSD-development,231365,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"alternative-id":["231365"],"URL":"https:\/\/doi.org\/10.36740\/wlek\/231365","relation":{},"ISSN":["0043-5147","2719-342X"],"issn-type":[{"value":"0043-5147","type":"print"},{"value":"2719-342X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}