{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:54:21Z","timestamp":1783727661767,"version":"3.55.0"},"reference-count":13,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>The aim: To explore the morphological changes of palatine tonsil at the levels of the epithelial layer and connective tissue; to determine the relative area of the connective tissue component in the tonsillar tissue (fibrosis) in patients with recurrent tonsillitis compared to the control. \nMaterials and methods: This study presents a morphological assessment of the palatine tonsils of 10 people. Tonsils\u2019 material with surrounding tissue was fixed in 10% formalin solution. The samples were dehydrated in increasing ethanol concentrations, cleared in xylol, impregnated with paraffin. Microscopy was then performed with samples stained beforehand. \nResults: In the samples of patients with recurrent tonsillitis pericapsular sclerosis was noted, along with thickening of interlobular septa and pronounced subepithelial fibrosis. A ratio of the dense connective tissue surface area to the total surface area of tonsil tissue was determined. The control group showed a statistically significant decrease in the degree of sclerosis of the tonsil stroma. \nConclusions: Multiple changes were found in the tonsils of patients with recurrent tonsillitis at the level of the epithelial layer that manifested in structural alterations. Significant and irreversible changes were also observed in the connective stroma of the tonsil - pericapsular sclerosis, thickening of interlobular septa, and pronounced subepithelial fibrosis. A statistically significant increase in the relative surface area of the connective tissue component of the tonsil (fibrosis) by a factor of 1,26 was noted in patients with recurrent tonsillitis compared to the results of the control group of patients.<\/jats:p>","DOI":"10.36740\/wlek202206102","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T13:26:44Z","timestamp":1657978004000},"page":"1434-1438","source":"Crossref","is-referenced-by-count":2,"title":["FEATURES OF THE CONNECTIVE TISSUE COMPONENT OF THE PALATINE TONSILS IN PATIENTS WITH RECURRENT TONSILLITIS"],"prefix":"10.36740","volume":"75","author":[{"given":"Ruslana M.","family":"Orlovska","sequence":"first","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasyl I.","family":"Popovych","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanna V.","family":"Koshel","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olexandr O.","family":"Bondarenko","sequence":"additional","affiliation":[{"name":"DNIPRO STATE MEDICAL UNIVERSITY, DNIPRO, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref0","unstructured":"1. Lutsyk O.D., Tchaikovsky Yu.B., Barinov E.F. Histology. Cytology. Embryology. Vinnytsia: Nova Knyha. 2018, 592 p. (in Ukrainian)"},{"key":"ref1","unstructured":"2. Therapie entz\u00fcndlicher Erkrankungen der Gaumenmandeln \/ Tonsillitis [Internet]. Bonn: DGHNO\/ 2015. https:\/\/www.awmf.org\/uploads\/ tx_szleitlinien\/017-024l_S2k_Tonsillitis_Gaumenmandeln_2015- 08-abgelaufen.pdf\/ [date access 09.01.2022]"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Olofsson K., Hellstrom S., Hammarstrom M.L. Human uvula: characterization of resident leukocytes and local cytokine production. Ann Otol Rhinol Laryngol. 2000; 109 (5): 488-96. doi: 10.1177\/000348940010900509.","DOI":"10.1177\/000348940010900509"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Dal Rio A.C., Passos C.A., Nicola J.H., Nicola E.M. CO2 laser cryptolysis by coagulation for the treatment of halitosis. 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Eur Arch Otorhinolaryngol. 2017;274(7):2927- 32. doi: 10.1007\/s00405-017-4575-y.","DOI":"10.1007\/s00405-017-4575-y"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T13:26:51Z","timestamp":1657978011000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2022\/06\/WLek202205102.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022]]},"published-print":{"date-parts":[[2022,6]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202206102","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}