{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:22:44Z","timestamp":1777508564970,"version":"3.51.4"},"reference-count":26,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>The aim: To study the features of morphoethiopathogenesis of acute appendicitis and the consequences after appendectomy. \nMaterials and methods: 10 preparations of human appendix were studied, from which 5 appendixes were normal in people who died in adulthood and old age and 5 processes were taken intraoperatively during appendectomy. Morphometric characteristics of the tissue structures of the preparations were compared with the systematic review data, the literature search by the following keywords: morphoethiopathy\u201d, \u201cvermiform process\u201d, \u201clymphoepithelial formations\u201d, \u201cdigestive system\u201d, \u201clymphoid nodule\u201d, \u201cPeyer\u2019s patches\u201d, \u201cmucous membrane\u201d. \nResults: Pathogenesis of acute appendicitis \u2013 it is a consistent, staged process that is completely subject to the laws of exudative inflammation in response to microbial aggression. Removal of the appendicular process should be approached carefully and based on possible immunological consequences. Removal of the appendix as an immunocompetent organ \nUnreasonable removal of pathohistological unchanged appendix has medical consequences (can lead to consequences such as colon cancer) and not only. \nConclusions: Our results suggest that the vermiform appendix retains its active function throughout human life. The study provides an overview with current knowledge about the etiology, pathogenesis and possible consequences of appendectomy as the main method of treatment of acute appendicitis. The search for ways to prevent appendicitis can be successful only by finding out the causes and factors that in some individuals cause the inability of the appendix to resist bacterial invasion. Appendix is necessary to fully support the immune responses of the digestive tract, but it belongs to the category of those organs, the loss of which during forced surgery does not cause significant damage to the body.<\/jats:p>","DOI":"10.36740\/wlek202206112","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T13:28:19Z","timestamp":1657978099000},"page":"1492-1499","source":"Crossref","is-referenced-by-count":7,"title":["PECULIARITIES OF MORPHOETIOPATHOGENESIS OF ACUTE APPENDICITIS AND CONSEQUENCES AFTER APPENDECTOMY"],"prefix":"10.36740","volume":"75","author":[{"given":"Volodymyr H.","family":"Hryn","sequence":"first","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaliy S.","family":"Drabovskiy","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmytro A.","family":"Sytnik","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman M.","family":"Ryabuschko","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhii M.","family":"Bilash","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohdan I.","family":"Gonzhak","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref0","unstructured":"1. Hryn V.H. Budova ileotsekalnoho viddilu kyshechnyku liudyny z intaktnym apendyksom ta pislia apendektomii [Structure of ileocecal part of human intestine with intact appendix and after appendectomy] : [avtoreferat]. Kharkiv: Kharkivskyi natsionalnyi medychnyi universytet. 2013, 19\u0440. (in Ukrainian)"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"2. Kooij I.A., Sahami S., Meijer S.L. et al. The immunology of the vermiform appendix: a review of the literature. Clin Exp Immunol. 2016;186(1):1-9. doi: 10.1111\/cei.12821.","DOI":"10.1111\/cei.12821"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"3. Coccolini F., Improta M., Sartelli M. et al. Acute abdomen in the immunocompromised patient: WSES, SIS-E, WSIS, AAST, and GAIS guidelines. World J Emerg Surg. 2021;40:16. doi: 10.1186\/s13017-021- 00380-1.","DOI":"10.1186\/s13017-021-00380-1"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Cibert-Goton V., Kung V.W.S., McGuire C. et al. Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly? Pain. 2020;161(4):773-786. doi: 10.1097\/j. pain.0000000000001764.","DOI":"10.1097\/j.pain.0000000000001764"},{"key":"ref4","unstructured":"5. Nitecki S., Karmeli R., Sarr M.G. Appendiceal calculi and fecaliths as indications for appendectomy. Surg Gynecol Obstet. 1990;171(3):185-8."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Raahave D., Christensen E., Moeller H. et al. Origin of acute appendicitis: fecal retention in colonic reservoirs: a case control study. Surg Infect. 2007;8(1):55-62. doi: 10.1089\/sur.2005.04250.","DOI":"10.1089\/sur.2005.04250"},{"key":"ref6","unstructured":"7. Dorado H.J., Daneri I. Acute hematogenous appendicitis. Prensa Med Argent. 1954;41(2):130-2."},{"key":"ref7","unstructured":"8. Hryn V.H. Osobennosty stroenyia slyzystoi obolochky yleotsekalnoi zaslonky pry yntaktnom appendykse y posle appendektomyy [Features of the structure of the mucous membrane of the ileocecal valve with an intact appendix and after appendectomy]. Visnyk problem biolohii i medytsyny. 2012; 2(93):185\u2013188. (in Ukrainian)."},{"key":"ref8","unstructured":"9. Zakharova G.N., Shekhov V.P. Rol\u2019allergicheskogo faktora v patogeneze ostrogo appenditsita [The role of the allergic factor in the pathogenesis of acute appendicitis]. Klin Med. 1968;46(8):19-24. (in Russian)."},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Smith M.C., Chung P.J., Constable Y.C. et al. Appendectomy in patients with human immunodeficiency virus: Not as bad as we once thought. Surgery. 2017;161(4):1076-1082. doi: 10.1016\/j.surg.2016.09.035.","DOI":"10.1016\/j.surg.2016.09.035"},{"key":"ref10","unstructured":"11. St\u0103nescu D., Sternberg D., Chiril\u0103 R. et al. Investigations virologiques sur certaines appendicites [Virological research on appendicitis]. Virologie. 1988;39(1):41-6. (in French)."},{"key":"ref11","unstructured":"12. Hroma V.H. Kliniko-anatomichni paraleli u khvorykh z hostrymy porushenniamy bryzhovoho krovotoku [Clinical and anatomical parallels in patients with acute mesenteric disorders]. Medychni perspektyvy. 2011;16(4):70-74. (in Ukrainian)."},{"key":"ref12","unstructured":"13. Drabovskyi V.S., Malyk S.V., Avetikov D.S. Biomekhanichni aspekty polipshennia rezultativ estetychnykh operatsii na perednii cherevnii stintsi [Biomechanical aspects of improving the results of aesthetic operations on the anterior abdominal wall]. Klinichna khirurhiia. 2015;11 (880):31-33. (in Ukrainian)."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Reinisch A., Heil J., Woeste G. et al. The meteorological influence on seasonal alterations in the course of acute appendicitis. J Surg Res. 2017;217:137-143. doi: 10.1016\/j.jss.2017.05.015.","DOI":"10.1016\/j.jss.2017.05.015"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Fischetti V.A. Novel method to control pathogenic bacteria on human mucous membranes. Ann N Y Acad Sci. 2003;987:207-14. doi: 10.1111\/ j.1749-6632.2003.tb06050.x.","DOI":"10.1111\/j.1749-6632.2003.tb06050.x"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Peeters T., Penders J., Smeekens S.P. et al. The fecal and mucosal microbiome in acute appendicitis patients: an observational study. Future Microbiol. 2019;14:111-127. doi: 10.2217\/fmb-2018-0203.","DOI":"10.2217\/fmb-2018-0203"},{"key":"ref16","unstructured":"17. Larbcharoensub N., Boonsakan P., Kanoksil W. et al. Fungal appendicitis: a case series and review of the literature. Southeast Asian J Trop Med Public Health. 2013;44(4):681-9."},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Sartori D.J., Sun K., Hopkins M.A. et al. Typhoid Fever and Acute Appendicitis: A Rare Association Not Yet Fully Formed. Case Rep Gastroenterol. 2017;11(2):446-451. doi: 10.1159\/000479310.","DOI":"10.1159\/000479310"},{"key":"ref18","unstructured":"19. Polishchuk F.A., Sheinbaum M.P. Sochetanie ostrogo appenditsita i ostro\u012d dizenterii u dete\u012d [Association of acute appendicitis and acute dysentery in children]. Khirurgiia. 1977;(4):124-5. (in Russian)."},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Hubbard G., Chlysta W. Tuberculous appendicitis: A review of reported cases over the past 10 years. J Clin Tuberc Other Mycobact Dis. 2021;23:100-28. doi: 10.1016\/j.jctube.2021.100228.","DOI":"10.1016\/j.jctube.2021.100228"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Dimberg J., Rub\u00e9r M., Skarstedt M. et al. Genetic polymorphism patterns suggest a genetic driven inflammatory response as pathogenesis in appendicitis. Int J Colorectal Dis. 2020;35(2):277-284. doi: 10.1007\/ s00384-019-03473-1.","DOI":"10.1007\/s00384-019-03473-1"},{"key":"ref21","unstructured":"22. Jones M.W., Godana I., Hoilat G.J. et al. Pseudoappendicitis. Treasure Island. 2021. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/ NBK499946\/ [date access 12.08.2021]"},{"key":"ref22","unstructured":"23. Kapustianskyi D.V. Diahnostychno-likuvalnyi alhorytm khvorykh na hostryi apendytsyt ta yoho uskladnennia [Diagnostic and therapeutic algorithm for patients with acute appendicitis and its complications]. Aktualni problemy suchasnoi medytsyny: Visnyk ukrainskoi medychnoi stomatolohichnoi akademii. 2012 ;3(39):134-138. (In Ukrainian)."},{"key":"ref23","unstructured":"24. Kapustianskyi D.V. Histolohichna struktura vydalenykh chervopodibnykh vidrostkiv u khvorykh na hostryi apendytsyt Svit medytsyny ta biolohii. [Histological structure of removed appendixes in patients with acute appendicitis]. Svit medytsyny ta biolohii. 2009. 5(31):72-75. (In Ukrainian)."},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Bijnen C.L., van den Broek W.T., Bijnen A.B. et al. Implications of removing a normal appendix. Dig Surg. 2003;20(3):215-9. doi: 10.1159\/000070388.","DOI":"10.1159\/000070388"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"26. Catal O., Ozer B., Sit M. et al. Is appendectomy a simple surgical procedure? Cir Cir. 2021;89(3):303-308. doi: 10.24875\/CIRU.20001277.","DOI":"10.24875\/CIRU.20001277"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T13:28:31Z","timestamp":1657978111000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2022\/06\/WLek202205112.pdf"}},"subtitle":[],"editor":[{"given":"Mykola M.","family":"Riabuschko","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022]]},"published-print":{"date-parts":[[2022,6]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202206112","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}