{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T14:11:01Z","timestamp":1657980661183},"reference-count":17,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>The aim: To investigate the effect of S-ademetionine on plasma citrulline level in patients with chronic lymphoproliferative disorders (CLPD) during chemotherapy-induced oxidative stress. \nMaterials and methods: 25 patients with CLPD were examined. Examinations were conducted twice: before chemotherapy (CT) and after 3 courses of CT. Several biochemical markers in the blood were determined: the activity of catalase, the level of plasma citrulline, the concentration of N-acetylneuraminic acid (NANA) and the concentration of substances that form a trimethine complex (TBARS) with 2-thiobarbituric acid. Patients were divided into groups: \u0406 (n=14) \u2013 patients who underwent only CT; \u0406\u0406 (n=16) \u2013 patients who during CT received S-ademetionine, at a dose of 1000 mg\/day intravenously for 10 days, then 500 mg twice a day for 20 days. \u0406\u0406\u0406 (n=20) \u2013the control group of 20 practically healthy individuals. \nResults: Patients in both groups with CLPD had pre-existed mucosal injury that was characterized by 1.25 (p=0.0025) and 1.26 times (\u0440=0.006) higher blood NANA concentration compared to the control group. The conduction of CT was associated with enterocytes dysfunction, which was characterized by 1,66 times (p=0,0002) lower plasma citrulline level in patients of group I compared to the initial examination. The infusion of S-ademetionine attenuated intestinal dysfunction that was associated with 1,23 times (p=0,0005) higher blood citrulline level after the CT as compared to group I. \nConclusions: The infusion of S-ademetionine as adjuvant treatment in patients with CLPD provided effective prophylaxis of intestinal injury that was associated with higher blood citrulline level after the conduction of CT.<\/jats:p>","DOI":"10.36740\/wlek202206123","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T13:28:55Z","timestamp":1657978135000},"page":"1553-1557","source":"Crossref","is-referenced-by-count":0,"title":["THE EFFECT OF S-ADEMETIONINE ON PLASMA CITRULLINE LEVEL DURING CHEMOTHERAPY-INDUCED OXIDATIVE STRESS IN PATIENTS WITH CHRONIC LYMPHOPROLIFERATIVE DISORDERS"],"prefix":"10.36740","volume":"75","author":[{"given":"Roman \u0406.","family":"Skrypnyk","sequence":"first","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganna S.","family":"Maslova","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor N.","family":"Skrypnyk","sequence":"additional","affiliation":[{"name":"POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1. 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