{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:03:46Z","timestamp":1788303826697,"version":"build-2803163510"},"reference-count":27,"publisher":"ALUNA","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>The aim: To estimate anti-inflammatory action of coxibs (3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one, 2,3,5,6-tetradeuterio-4-[5-(4-methylphenyl)-3-(trifluoromethyl) pyrazol-1-yl]benzenesulfonamide) compared to reference drug \u2013 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt. \nMaterials and methods: The anti-inflammatory effect of studied substances was investigated using the ceruloplasmin test as serum ceruloplasmin is a routinely investigated biochemical index. Formalin-induced hind paw edema was used as the most commonly used animal model to simulate acute inflammation. 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one (1.5 mg\/kg) and celecoxib (5 mg\/kg) were administrated intragastrically in 4 hours after induction of inflammation with formalin. The ceruloplasmin level in the serum was investigated using the Ravin\u2019s method. \nResults: The levels of serum ceruloplasmin under conditions of formalin edema was 3.11 \u00b1 0.02 \u03bcmol\/L, that is 2.5 times greater than in intact animals. It was shown that at the injection of 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one serum \u0441eruloplasmin level demonstrated a statistically significant reduction in comparison with formalin edema. There is no statistically significant difference between groups. 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one affected the serum ceruloplasmin levels in rats under the conditions of formalin edema effectively. 2,3,5,6-tetradeuterio-4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide had only tendency to decrease the inflammatory marker ceruloplasmin in serum of rats in reference to formalin edema. \nConclusions: Results of biochemical research of the effect of coxibs on the serum ceruloplasmin level in rats show that 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one has marked anti-inflammatory activity while 2,3,5,6-tetradeuterio-4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide has only tendency to decrease the inflammatory marker ceruloplasmin in serum of rats.<\/jats:p>","DOI":"10.36740\/wlek202209103","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T14:17:45Z","timestamp":1666189065000},"page":"2065-2069","source":"Crossref","is-referenced-by-count":1,"title":["EXPERIMENTAL RESEARCH OF THE EFFECT OF COXIBS ON THE CERULOPLASMIN LEVEL IN RAT SERUM ON THE FORMALIN-INDUCED EDEMA MODEL"],"prefix":"10.36740","volume":"75","author":[{"given":"Ganna O.","family":"Syrova","sequence":"first","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena V.","family":"Savelieva","sequence":"additional","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetyana S.","family":"Tishakova","sequence":"additional","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larysa V.","family":"Luk\u0456\u0430nova","sequence":"additional","affiliation":[{"name":"KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. 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Microcirc. 2017;67(3-4):241-250. doi: 10.3233\/CH-179205.","DOI":"10.3233\/ch-179205"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T14:18:19Z","timestamp":1666189099000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2022\/09\/WLek202209103.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022]]},"published-print":{"date-parts":[[2022,9]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202209103","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}