{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:56:04Z","timestamp":1768456564045,"version":"3.49.0"},"reference-count":25,"publisher":"ALUNA","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>The aim: To determine the clinical and the genetic association of the COMT rs4680 SNP in women with FMS. \nMaterials and methods: Extracted DNA from peripheral blood samples were utilized as template for the PCR and RFLP analysis. \nResults: A significant difference was found in the distribution of the COMT genotype between FMS patients and controls (P&lt;0.05). The frequency of GG, AG, AA genotypes were 12%, 72%, 21% in FMS patients and 32%, 62%, 11% in controls. The clinical features of FMS reveal that FIQR and the severity of pain measured by VAS were significantly associated with the COMT rs4680 SNP (P=0.042; P=0.016). The co-dominant model for GG verse v. AG genotype (P=0.004) and AG v. AA genotype (P=0.002) has shown to be high risk for FMS. An increased risk of FMS in the dominant model for (AG+AA) v. GG genotype (P=0.001) and no significant difference was found between (GG+AG) v. AA genotype (P=0.08) in the recessive model. The result indicated that A allele considerably increase the risk of FMS (P=0.004) in comparison to the G allele. \nConclusions: AA genotype and A allele of the COMT rs4680 SNP were significantly associated with severity in FMS patients and also plays a significant role in the clinical manifestation of this disease.<\/jats:p>","DOI":"10.36740\/wlek202210123","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T19:31:11Z","timestamp":1670614271000},"page":"2439-2444","source":"Crossref","is-referenced-by-count":2,"title":["UNRAVELING THE CLINICO-GENETIC ASSOCIATION OF CATECHOL-O-METHYLTRANSFERASE-RS4680 G&gt;A GENE POLYMORPHISM IN WOMEN WITH FIBROMYALGIA SYNDROME"],"prefix":"10.36740","volume":"75","author":[{"given":"Sidrah","family":"Parvez","sequence":"first","affiliation":[{"name":"ERA UNIVERSITY, LUCKNOW, INDIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghizal","family":"Fatima","sequence":"additional","affiliation":[{"name":"ERA UNIVERSITY, LUCKNOW, INDIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzana","family":"Mahdi","sequence":"additional","affiliation":[{"name":"ERA UNIVERSITY, LUCKNOW, INDIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Fedacko","sequence":"additional","affiliation":[{"name":"PAVOL JOZEF SAFARIK UNIVERSITY, KOSICE, SLOVAKIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najah R.","family":"Hadi","sequence":"additional","affiliation":[{"name":"UNIVERSITY OF KUFA, KUFA, IRAQ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1. 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