{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:10:08Z","timestamp":1782821408496,"version":"3.54.5"},"reference-count":17,"publisher":"ALUNA","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>The aim: To study the distribution and influence of coagulation factor gene polymorphisms, endothelial dysfunction, blood pressure regulator on the development of obstetric and perinatal complications in women with preeclampsia (PE). \nMaterials and methods: The prospective cohort study included 46 women with PE and maternal or fetal complications and 87 pregnant women with PE, without complications. Genetic polymorphisms of coagulation factors and fibrinolysis (1691 G\u2192A FVL, 20210 G\u2192A prothrombin, 675 5G\/4G PAI-1, 455 G\u2192A fibrinogen \u03b2), endothelial dysfunction (192 Q\u2192R PON-1, 677 C\u2192T MTHFR) and blood pressure regulator (235 M\u2192T angiotensinogen II) were studied with the help of allele-specific polymerase chain reaction \nResults: Markers of predisposition to the development of obstetric and perinatal complications in pregnant women with PE are the following genotypes: 1691 GA by V Leiden factor gene \u2013 increases the risk in 2.9 times (95% CI 1.94-4.33), 20210 GA by prothrombin gene \u2013 in 2.36 times (95% CI 1.54-3.6), 20210 AA by prothrombin gene \u2013 in 3.12 times (95% CI 2.4-4.0). Pathological polymorphisms in the genes of angiotensinogen II 235 M\u2192T, PAI-1 5G\/4G, fibrinogen \u03b2 455 G\u2192A, paraoxonase-1 192 Q\u2192R do not significantly affect the development of complications during preeclampsia. \nConclusions: The development of PE against the background of the existence of acquired and hereditary types of thrombophilia is associated with a more severe course, early-onset and the development of life-threatening complications for a mother and fetus.<\/jats:p>","DOI":"10.36740\/wlek202212113","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T17:34:54Z","timestamp":1675272894000},"page":"2969-2973","source":"Crossref","is-referenced-by-count":6,"title":["RISK OF PLACENTA-ASSOCIATED COMPLICATIONS AT PREECLAMPSIA IN PREGNANT WOMEN WITH THROMBOPHILIA"],"prefix":"10.36740","volume":"75","author":[{"given":"Tetiana","family":"Loskutova","sequence":"first","affiliation":[{"name":"DNIPRO STATE MEDICAL UNIVERSITY, DNIPRO, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Donskay","sequence":"additional","affiliation":[{"name":"DNIPRO STATE MEDICAL UNIVERSITY, DNIPRO, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Petulko","sequence":"additional","affiliation":[{"name":"DNIPRO STATE MEDICAL UNIVERSITY, DNIPRO, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataly","family":"Kryachkova","sequence":"additional","affiliation":[{"name":"DNIPRO STATE MEDICAL UNIVERSITY, DNIPRO, UKRAINE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. 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