{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T05:40:29Z","timestamp":1675316429456},"reference-count":19,"publisher":"ALUNA","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>The aim: To optimize the differential diagnosis of bacterial pneumonia and tuberculosis in HIV-positive patients based on the value of serum seromucoid. \nMaterials and methods: The study included 77 HIV-positive patients with lung pathology. The 1st group consisted of 44 HIV-infected patients with BP; the 2nd group \u2013 of 33 patients with HIV\/TB co-infection. Level of SSM, CD4+ T-lymphocytes, HIV-1 RNA viral load was determined. \u0421linical, laboratory, microscopic, radiological, microbiological, and statistical methods were used in the research. \nResults: In patients with HIV\/TB co-infection CD4+ T-lymphocyte level was lower, and viral load was higher than in HIV-infected patients with BP. The level of SSM was statistically significantly elevated in patients of both groups compared with the control (p&lt;0,001), but in patients with HIV\/TB co-infection the values were statistically significantly higher (p&lt;0,001). In patients with BP, the content of SSM\u226415,95 TU occurred statistically significantly more often than in patients with TB (\u03c72= 65,5; p &lt;0,001). No statistically significant relationship between SSM content and CD4+ T-lymphocyte levels was found. \nConclusions: The content of SSM in patients with HIV\/TB co-infection is statistically significantly higher than in the group of HIV-infected patients with BP. Determination of SSM level can be used as a rapid method of differential diagnosis of BP and TB in HIV-positive patients that will allow to optimize the diagnostic algorithm at the early stage of hospitalization and to receive the necessary timely treatment for HIV-infected patients.<\/jats:p>","DOI":"10.36740\/wlek202212124","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:26:10Z","timestamp":1675275970000},"page":"3036-3040","source":"Crossref","is-referenced-by-count":0,"title":["THE VALUE OF SERUM SEROMUCOID IN THE DIFFERENTIAL DIAGNOSIS OF BACTERIAL PNEUMONIA AND TUBERCULOSIS IN HIV-POSITIVE PATIENTS"],"prefix":"10.36740","volume":"75","author":[{"given":"Olena V.","family":"Tsyko","sequence":"first","affiliation":[{"name":"NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr M.","family":"Kozko","sequence":"additional","affiliation":[{"name":"NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kateryna V.","family":"Yurko","sequence":"additional","affiliation":[{"name":"NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganna O.","family":"Solomennyk","sequence":"additional","affiliation":[{"name":"NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena I.","family":"Mohylenets","sequence":"additional","affiliation":[{"name":"NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina F.","family":"Merkulova","sequence":"additional","affiliation":[{"name":"NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. 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(In Russian)."}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:27:19Z","timestamp":1675276039000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2022\/12\/WLek202212124.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":19,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202212124","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}