{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T05:39:20Z","timestamp":1675316360432},"reference-count":27,"publisher":"ALUNA","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>The aim: To study the possibilities of alpha-lipoic acid (ALA) to control the parameters of carbohydrate metabolism. \nMaterials and methods: We examined 80 people with type 2 DM and coronary heart disease who suffered non-Q-myocardial infarction (non-Q-MI). All patients at the time of inclusion in the study received oral hypoglycemic agents, ACE inhibitor, \u03b2-blocker, statin and antiplatelet agent. 600 mg of ALA per day for 4 months was added to this treatment. After checking the patients for compliance with the criteria, they were divided into the main and experimental groups. The dosage of alpha-lipoic acid was determined for each of the groups. The results of the treatment were analyzed by determining the mean and standard deviations. \nResults: At the end of the observation period, a significant decrease in the level of fasting glucose (FG) by 11.6% was found, which corresponded to the average size of the clinical effect. The values of glycosylated hemoglobin (HbA1c) and the insulin resistance index HOMA (HOMA-IR) showed only a tendency to decrease on the background of treatment. The effect of ALA on postprandial glycemia (PPG) and insulin levels was not detected in this study. \nConclusions: An additional 4-month dose of ALA in addition to baseline therapy showed a moderate effect on the decrease in FG concentration in the absence of significant dynamics in other parameters of glycemic control in the examined patients.<\/jats:p>","DOI":"10.36740\/wlek202212131","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:24:45Z","timestamp":1675275885000},"page":"3074-3079","source":"Crossref","is-referenced-by-count":0,"title":["EFFECTS OF ALPHA-LIPOIC ACID ON GLYCEMIC STATUS IN 2 TYPE DIABETES PATIENTS WITH \u0421HRONIC CORONARY SYNDROME"],"prefix":"10.36740","volume":"75","author":[{"given":"Nataliia","family":"Altunina","sequence":"first","affiliation":[{"name":"O.O. BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr","family":"Bondarchuk","sequence":"additional","affiliation":[{"name":"O.O. BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Naito R., Miyauchi K. Coronary Artery Disease and Type 2 Diabetes Mellitus. Int Heart J. 2017; 58 (4): 475\u2013480. doi: 10.1536\/ihj.17-191.","DOI":"10.1536\/ihj.17-191"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Pervaiz R., Ercantan O. The burden of non-communicable diseases in relation to economic status of countries. Biomedical Research and Therapy. 2018;5(1):1967\u20131974. doi: 10.15419\/bmrat.v5i1.411.","DOI":"10.15419\/bmrat.v5i1.411"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. 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J Med Food. 2018; 21(3): 269\u2013273. doi: 10.1089\/jmf.2017.0068.","DOI":"10.1089\/jmf.2017.0068"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:40:36Z","timestamp":1675276836000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2022\/12\/WLek202212131.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202212131","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}