{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T10:14:32Z","timestamp":1688120072588},"reference-count":16,"publisher":"ALUNA","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>The aim: To de!ne regularities of testicular construction of the rats\u2019 offspring at 1-90 days of postnatal life after the introduction of female sex hormones to pregnant rats during the second and third periods of pregnancy \nMaterials and methods: The study was conducted on the testes of white laboratory rats\u2019 offspring during three months of life. Pregnant rats were exposed to intravaginal injection of Utrozhestan during the second and third periods of pregnancy. histological methods were used. Analysis of the obtained results was conducted by means of statistical methods with the use of computer license program &amp;#171;Statistica for Windows 13&amp;#187; (StatSoft Inc., # JPZ804I382130ARCN10-J). \nResults: Administration of female sex hormones to pregnant female rats leads to a reducing of the relative area, occupied by the convoluted seminiferous tubules with lumen, and increasing in relative area, occupied by extracellular matrix, starting from the 30th and up to the 90th observation day in the offsprings\u2019 testes. During the third month after birth, in experimental group a decreasing of the testicles\u2019 spermatids di\"erentiation degree is determined \nConclusions: During the study, the following results and conclusions were obtained: decreasing of the relative area, occupied by convoluted seminiferous tubules, increasing in relative area, occupied by extracellular matrix, also decreasing Leydig cells relative amount and a delaying of spermatid di\"erentiation process after exposing to female sex hormones during pregnancy, especially during third period, can lead to disruption of spermatogenesis and spermiogenesis in the future.<\/jats:p>","DOI":"10.36740\/wlek202302107","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T11:52:54Z","timestamp":1680522774000},"page":"292-296","source":"Crossref","is-referenced-by-count":0,"title":["STRUCTURAL PECULIARITIES OF RATS\u2019 TESTES DEVELOPMENT AFTER INTRODUCTION OF FEMALE HORMONES DURING PREGNANCY"],"prefix":"10.36740","volume":"76","author":[{"given":"Olena A.","family":"Hryhorieva","sequence":"first","affiliation":[{"name":"ZAPORIZHZHIA STATE MEDICAL UNIVERSITY, ZAPORIZHZHIA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetiana","family":"Topolenko","sequence":"additional","affiliation":[{"name":"ZAPORIZHZHIA STATE MEDICAL UNIVERSITY, ZAPORIZHZHIA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kateryna","family":"Kovalchuk","sequence":"additional","affiliation":[{"name":"ZAPORIZHZHIA STATE MEDICAL UNIVERSITY, ZAPORIZHZHIA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriy","family":"Guminskiy","sequence":"additional","affiliation":[{"name":"PIROGOV NATIONAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetyana","family":"Matveishyna","sequence":"additional","affiliation":[{"name":"ZAPORIZHZHIA STATE MEDICAL UNIVERSITY, ZAPORIZHZHIA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Grinivetska","sequence":"additional","affiliation":[{"name":"ZAPORIZHZHIA STATE MEDICAL UNIVERSITY, ZAPORIZHZHIA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandra","family":"Lazaryk","sequence":"additional","affiliation":[{"name":"ZAPORIZHZHIA STATE MEDICAL UNIVERSITY, ZAPORIZHZHIA, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. 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