{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:12:17Z","timestamp":1786389137771,"version":"build-2736575974"},"reference-count":30,"publisher":"ALUNA","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Mechanical heart compression, including that from mediastinal tumor, may cause Brugada-like ECG pattern. Such ECG pattern might also be observed in intracardiac tumor obstructing the right ventricular out\"ow tract (RVOT). Eight cases with Brugada-like ECG and tumors involving RVOT have been described so far; 4 growing in the mediastinum (with one example of in\"ammatory mass), 3 with intracardiac location, and 1 being an organized pericardial hematoma. The authors present other 3 cases of intracardiac metastatic tumors in RVOT and Brugada-like ECG pattern with coved ST-segment elevation in the right precordial leads. All patients had negative history of cardiovascular disease or familiar malignant arrhythmia occurrence. ECG were done routinely; none of the patients had chest pain or an increased level of cardiac troponins. In all patients, neoplastic disease was at advanced stage. A 76-year-old male, had a history of four neoplasms: bladder cancer was being treated with chemotherapy, while prostate, tongue, and lung cancers had been resected years ago and no signs of local relapse were found. A 78-year-old female, was diagnosed with colon cancer 1 month after an episode of venous thromboembolism. Six months after the resection of cancer, second focus of adenocarcinoma was found in the rectum. Third patient, a 65-year-old-male had undergone nephrectomy for renal cancer a year before cardiac metastasis diagnosis.<\/jats:p>","DOI":"10.36740\/wlek202302130","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T11:51:57Z","timestamp":1680522717000},"page":"452-457","source":"Crossref","is-referenced-by-count":4,"title":["BRUGADA-LIKE ECG PATTERN AND TUMORS INVOLVING RIGHT VENTRICULAR OUTFLOW TRACT - CASE SERIES AND LITERATURE REVIEW"],"prefix":"10.36740","volume":"76","author":[{"given":"Waldemar","family":"Elikowski","sequence":"first","affiliation":[{"name":"DEPARTMENT OF INTERNAL MEDICINE, J\u00d3ZEF STRUS HOSPITAL, POZNAN, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ferta\u0142a","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF INTERNAL MEDICINE, J\u00d3ZEF STRUS HOSPITAL, POZNAN, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Zawodna-Marsza\u0142ek","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF INTERNAL MEDICINE, J\u00d3ZEF STRUS HOSPITAL, POZNAN, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kwiecien-Zaparty","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF INTERNAL MEDICINE, J\u00d3ZEF STRUS HOSPITAL, POZNAN, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw","family":"\u0141azowski","sequence":"additional","affiliation":[{"name":"PATHOMORPHOLOGY UNIT, J\u00d3ZEF STRUS HOSPITAL, POZNAN, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Skrzywanek","sequence":"additional","affiliation":[{"name":"RADIOLOGY UNIT, J\u00d3ZEF STRUS HOSPITAL, POZNAN, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Zytkiewicz","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF INTERNAL MEDICINE, J\u00d3ZEF STRUS HOSPITAL, POZNAN, POLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Baranchuk A, Nguyen T, Ryu MH, et al. Brugada phenocopy: new terminology and proposed classi!cation. Ann Noninvasive Electrocardiol. 2012;17:299-314.","DOI":"10.1111\/j.1542-474x.2012.00525.x"},{"key":"ref1","unstructured":"2. Francis J, Antzelevitch C. Brugada-like electrocardiographic pattern. Indian Pacing Electrophysiol J. 2003;3:91-92."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Awad SF, Barbosa-Barros R, Belem Lde S, et al. Brugada phenocopy in a patient with pectus excavatum: systematic review of the ECG manifestations associated with pectus excavatum. Ann Noninvasive Electrocardiol. 2013;18:415-420.","DOI":"10.1111\/anec.12082"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"4. Kazmi F, Adil A, Miller S, et al. Trauma induced Brugada pattern.#J Am Coll Cardiol.#2019;73(S1):2924.","DOI":"10.1016\/S0735-1097(19)33530-2"},{"key":"ref4","unstructured":"5. Coppolino A, Valeri L. Pericardial E$usion and Brugada Type 1 Electrocardiogram Pattern. An Another Case of Brugada Phenocopy. Acta Scienti!c Clinical Case Reports. 2022;3(1): 59-64."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Barcos JC, Tello Santacruz IA, Moni\u00e9 CC, et al. Brugada phenocopy induced by severe pneumothorax. J Electrocardiol. 2018;51:343-345.","DOI":"10.1016\/j.jelectrocard.2017.10.016"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Khmao P, Long V, Ku N, et al. Brugada phenocopy or congenital Brugada syndrome in a patient with spontaneous pneumopericardium and pericarditis. J Arrhythm. 2020;37:246-248.","DOI":"10.1002\/joa3.12488"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Sasaki A, Nakazato Y. Brugada-like electrocardiogram detected after reconstructive operation for oesophageal cancer. Europace. 2010;12:1542.","DOI":"10.1093\/europace\/euq256"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Tar\u00edn N, Farr\u00e9 J, Rubio JM, et al. Brugada-like electrocardiographic pattern in a patient with a mediastinal tumor. Pacing Clin Electrophysiol. 1999; 22: 1264-1266.","DOI":"10.1111\/j.1540-8159.1999.tb00613.x"},{"key":"ref9","unstructured":"10. Nakazato Y, Ohmura T, Shimada I, et al. Brugada-like precordial ST elevation on ECG by anterior mediastinal infective mass lesion. Indian Pacing Electrophysiol J. 2003;3:184."},{"key":"ref10","unstructured":"11. Asteriou C, Lazopoulos A, Giannoulis N, et al. Brugada-like ECG pattern due to giant mediastinal lipoma. Hippokratia. 2013;17:368-369."},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. P\u00e9rez-Riera AR, Barbosa Barros R, Daminello-Raimundo R, et al. Brugada phenocopy caused by a compressive mediastinal tumor. Ann Noninvasive Electrocardiol. 2018;23:e12509.","DOI":"10.1111\/anec.12509"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Nguyen T, Smythe J, Baranchuk A. Rhabdomyoma of the interventricular septum presenting as a Brugada phenocopy. Cardiol Young. 2011;21:591-594.","DOI":"10.1017\/s1047951111000424"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"14. Sato N, Shimokawa M, Iwasaki H, et al. Brugada-Like ECG Associated with Primary Cardiac Lymphoma.#J Clin Experiment Cardiol. 2011;2:1-2.","DOI":"10.4172\/2155-9880.1000128"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Schnegg B, Seiler J, Suter TM, et al. Brugada Type 1 ECG Caused by an RVOT Tumor. Scienti!c Pages Heart. 2016;1:002.","DOI":"10.36959\/652\/382"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Tomcs\u00e1nyi J, Simor T, Papp L. Images in cardiology. Haemopericardium and Brugada-like ECG pattern in rheumatoid arthritis. Heart 2002;87:234.","DOI":"10.1136\/heart.87.3.234"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Antzelevitch C, Dumaine R. Electrical heterogeneity in the heart: physiological, pharmacological and clinical implications. In: The Handbook of Physiology. New York: Oxford Univ. Press, 2002, pp. 654-692.","DOI":"10.1002\/cphy.cp020117"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Kim YH, Lim HE, Kim SH, et al. Brugada-like ST-segment abnormalities associated with myocardial involvement of hematologic diseases. Pacing Clin Electrophysiol. 2008;31:761-764.","DOI":"10.1111\/j.1540-8159.2008.01082.x"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Tomiyama T, Shijimaya T, Sano Y, et al. Large Metastatic Cardiac Tumor from Ascending Colon Cancer with Autopsy. Case Rep Gastroenterol. 2021;15:703-708.","DOI":"10.1159\/000518022"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Briasoulis A, Siddiqui F, Siddiqui S, et al. Large right ventricular mass causing out\"ow tract obstruction secondary to metastatic renal cell carcinoma. Acta Cardiol. 2015;70:86-87.","DOI":"10.1080\/ac.70.1.3064600"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Briosa E, Gala A, Dimarco A, et al. Subtotal Obstruction of the Right Ventricular Out\"ow Tract Caused by Isolated Intracardiac Renal Cell Carcinoma Metastasis. Circ Cardiovasc Imaging. 2019;12:e009714.","DOI":"10.1161\/circimaging.119.009714"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Doshi TV, Doshi JV, Makaryus JN, et al. A rare case of successfully treated cardiac metastasis from transitional cell bladder cancer. Am J Ther. 2013;20:307-310.","DOI":"10.1097\/mjt.0b013e3181f6c131"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23. Chua S, Liu WH, Lee WC. Isolated huge right ventricular tumor: cardiac metastasis of tongue cancer. Korean J Intern Med. 2017;32:1119-1120.","DOI":"10.3904\/kjim.2016.143"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24. Demir V, Turan Y, Ede H, et al. Electrocardiographic changes in right ventricular metastatic cardiac tumor mimicking acute ST elevation myocardial infarction: A case of misdiagnosis. Turk J Emerg Med. 2018; 19: 33-35.","DOI":"10.1016\/j.tjem.2018.07.001"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Ya\u2019qoub L, Payne K, Parikh S, et al. A Right Ventricular Mass in a Patient with Squamous Cell Lung Cancer: A Case Report and Review of Literature. Cureus. 2018;10:e2261.","DOI":"10.7759\/cureus.2261"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26. Gopal AS, Stathopoulos JA, Arora N, et al. Di$erential diagnosis of intracavitary tumors obstructing the right ventricular out\"ow tract. J Am Soc Echocardiogr. 2001;14:937-940.","DOI":"10.1067\/mje.2001.114627"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Labib SB, Schick EC Jr, Isner JM. Obstruction of right ventricular out\"ow tract caused by intracavitary metastatic disease: analysis of 14 cases. J Am Coll Cardiol. 1992;19:1664-1668.","DOI":"10.1016\/0735-1097(92)90634-y"},{"key":"ref27","unstructured":"28. Elikowski W, \u0141azowski S, Ferta\u0142a N, et al. Brugada phenocopy in pulmonary embolism \u2013 clinicopathological case study and literature review. Pol Merkur Lekarski. 2022;50:378-383."},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29. Lazaros G, Lazarou E, Tousoulis D. Brugada phenocopy in a patient underdoing pericardiocentesis for a large idiopathic pericardial e$usion. J Electrocardiol. 2020;63:184-185.","DOI":"10.1016\/j.jelectrocard.2019.01.081"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30. Facin M, Pastore CA, Samesima N, et al. Ventricular repolarization abnormalities: the electrocardiographic track of cardiac tumoural involvement in an infant with tuberous sclerosis complex. A case report. Eur Heart J Case Rep. 2020; 4: 1-6.","DOI":"10.1093\/ehjcr\/ytaa025"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T09:57:45Z","timestamp":1688119065000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2023\/WLek2023021.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023,2]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202302130","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}