{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T04:30:54Z","timestamp":1689827454020},"reference-count":17,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>The aim: Traumatic Brain Injury (TBI) remains a significant health burden worldwide. This study aimed to describe, determine and recommendation concerning the impact of hyperglycemia on pediatric TBI. \nMaterials and methods: Paediatric trauma patients with severe TBI event were identified and admitted to our Dr. Soetomo General Hospital, Surabaya, the regional Trauma Center of East Java, Indonesia between calendar year of 2017 and 2022. Our institutions trauma database was utilized to select the patient included in this study. Patients with GCS \u2264 8 who underwent neurosurgical interventions were included to the study. Neurosurgical interventions are craniotomy for clot evacuation and decompressive craniectomy. We excluded patients with GCS &gt; 8 and\/or treated with conservative therapy (no surgery needed). Data collected for analysis as independent variables included patient age, admission GCS score and admission serum glucose score, mechanism of injury, type of intracranial lesion and type of surgery. Outcome of the patients included was examined at discharge which sub-grouped by Glasgow Outcomes Scale (GOS) score. Independent variables were entered into the logistic model in a stepwise fashion with a significant cutoff of p&lt; 0,05. \nResults: Patients with worse neurological outcomes (GOS score 1-2) had a mean serum glucose value of over 200 mg\/dL. Patients who died (GOS score of 1) had higher mean admission glucose values (226.44 \u00b1 62,00) than the patients who had survived with a GOS score of 3 (139.80 \u00b1 10.87), 4 (87), or 5 (134). Patients who resulted in a vegetative state (GOS score of 2) had higher mean admission serum glucose values than patients who were discharged with a GOS score of 5 (205.14 \u00b1 36.17 vs. 134; p = 0.003). \nConclusions: Hyperglycaemia in pediatric TBI patients that underwent neurosurgical intervention is associated with worse outcomes, even mortality. We believe that prospective evaluation of glucose normalization in the context of acute management of pediatric head injuries is both appropriate and necessary for the next study.<\/jats:p>","DOI":"10.36740\/wlek202306103","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T12:18:21Z","timestamp":1689769101000},"page":"1342-1346","source":"Crossref","is-referenced-by-count":0,"title":["HYPERGLYCEMIA AS A PREDICTOR OF OUTCOME IN PAEDIATRIC SEVERE TRAUMATIC BRAIN INJURY PATIENTS UNDERWENT SURGERY: A SINGLE CENTER EXPERIENCE FROM EASTERN INDONESIA FROM 2017-2022"],"prefix":"10.36740","volume":"76","author":[{"given":"Muhamad Arifin","family":"Parenrengi","sequence":"first","affiliation":[{"name":"UNIVERSITAS AIRLANGGA, SURABAYA, INDONESIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wihasto","family":"Suryaningtyas","sequence":"additional","affiliation":[{"name":"UNIVERSITAS AIRLANGGA, SURABAYA, INDONESIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rifqi Aulia","family":"Destiansyah","sequence":"additional","affiliation":[{"name":"UNIVERSITAS AIRLANGGA, SURABAYA, INDONESIA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Bandyopadhyay S, Kawka M, Marks K et al. Traumatic Brain Injury-Related Pediatric Mortality and Morbidity in Low- and Middle-Income Countries: A Systematic Review. World Neurosurg. 2021;153:109-130.e23. doi:10.1016\/j.wneu.2021.06.077.","DOI":"10.1016\/j.wneu.2021.06.077"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Dey S, Kumar R, Tarat A. Evaluation of Electrolyte Imbalance in Patients With Traumatic Brain Injury Admitted in the Central ICU of a Tertiary Care Centre: A Prospective Observational Study. Cureus. 2021;13(8):e17517. doi:10.7759\/cureus.17517.","DOI":"10.7759\/cureus.17517"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Chen S, Liu Z. Effect of hyperglycemia on all-cause mortality from pediatric brain injury: A systematic review and meta-analysis. Medicine (Baltimore). 2020;99(48):e23307. doi:10.1097\/MD.0000000000023307.","DOI":"10.1097\/md.0000000000023307"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Trimble DJ, Parker SL, Zhu L et al. Outcomes and prognostic factors of pediatric patients with a Glasgow Coma Score of 3 after blunt head trauma. Childs Nerv Syst. 2020;36(11):2657-2665. doi:10.1007\/s00381-020-04637-z.","DOI":"10.1007\/s00381-020-04637-z"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. El-Kheir MMA, Attia SM, Ahmed MES et al. Hyperglycemia as Prognostic Factor in Pediatric Traumatic Brain Injury in Emergency Hospital Mansoura University. Egypt J Hosp Med. 2022;87(1):2139\u20132146.","DOI":"10.21608\/ejhm.2022.233184"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Chen CH, Hsieh YW, Huang JF et al. Predictors of In-Hospital Mortality for Road Traffic Accident-Related Severe Traumatic Brain Injury. J Pers Med. 2021;11(12):1339. doi:10.3390\/jpm11121339.","DOI":"10.3390\/jpm11121339"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Fanchiang S-P, Indraghanty A, Liu H et al. Post-Traumatic Brain Injury (TBI) Blood Sugar (BG) and its Relation to Inpatient Rehabilitation Outcome. Archives of Physical Medicine and Rehabilitation, 2023;104(3):e44. doi: 10.1016\/j.apmr.2022.12.127.","DOI":"10.1016\/j.apmr.2022.12.127"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Seyed Saadat SM, Bidabadi E, Seyed Saadat SN et al. Association of persistent hyperglycemia with outcome of severe traumatic brain injury in pediatric population. Childs Nerv Syst. 2012;28(10):1773-1777. doi:10.1007\/s00381-012-1753-5.","DOI":"10.1007\/s00381-012-1753-5"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Rizoli SB, Jaja BN, Di Battista AP et al. Catecholamines as outcome markers in isolated traumatic brain injury: the COMA-TBI study. Crit Care. 2017;21(1):37. doi:10.1186\/s13054-017-1620-6.","DOI":"10.1186\/s13054-017-1620-6"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Shi J, Dong B, Mao Y et al. Review: Traumatic brain injury and hyperglycemia, a potentially modifiable risk factor. Oncotarget. 2016;7(43):71052-71061. doi:10.18632\/oncotarget.11958.","DOI":"10.18632\/oncotarget.11958"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Orellana RA, Coss-Bu JA. Metabolic alterations in the critically ill child. Pediatr Med. 2021;4:1\u201317.","DOI":"10.21037\/pm-20-64"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Shukla V, Shakya AK, Perez-Pinzon MA et al. Cerebral ischemic damage in diabetes: an inflammatory perspective. J Neuroinflammation. 2017;14(1):21. doi:10.1186\/s12974-016-0774-5.","DOI":"10.1186\/s12974-016-0774-5"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Hermanides J, Plummer MP, Finnis M et al. Glycaemic control targets after traumatic brain injury: a systematic review and meta-analysis. Crit Care. 2018;22(1):11. doi:10.1186\/s13054-017-1883-y.","DOI":"10.1186\/s13054-017-1883-y"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Chao M, Wang CC, Chen CPC et al. The Influence of Serious Extracranial Injury on In-Hospital Mortality in Children with Severe Traumatic Brain Injury. J Pers Med. 2022;12(7):1075. doi:10.3390\/jpm12071075.","DOI":"10.3390\/jpm12071075"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Rostami E. Glucose and the injured brain-monitored in the neurointensive care unit. Front Neurol. 2014;5:91. doi:10.3389\/fneur.2014.00091.","DOI":"10.3389\/fneur.2014.00091"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Sharma D, Jelacic J, Chennuri R et al. Incidence and risk factors for perioperative hyperglycemia in children with traumatic brain injury. Anesth Analg. 2009;108(1):81-89. doi:10.1213\/ane.0b013e31818a6f32.","DOI":"10.1213\/ane.0b013e31818a6f32"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Agus MS, Hirshberg E, Srinivasan V et al. Design and rationale of Heart and Lung Failure - Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children. Contemp Clin Trials. 2017;53:178-187. doi:10.1016\/j.cct.2016.12.023.","DOI":"10.1016\/j.cct.2016.12.023"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T12:24:27Z","timestamp":1689769467000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2023\/WiadLek2023i6.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023,6]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202306103","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}