{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T04:30:37Z","timestamp":1689827437153},"reference-count":11,"publisher":"ALUNA","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>The aim: To perform a clinical analysis of bronchiectasis in adults, to analyze the effectiveness of nebulizer therapy with hypertonic NaCl solution with hyaluronic acid \nMaterials and methods: All patients were performed clinical-functional examination (MRC dyspnea index, Sp O2, 6-minute walking test, external respiration function); calculated the index BODE, analyzed the SGRQ, studied the results of sputum. Statistical data analysis was performed using the Microsoft Excel for Microsoft 365 MSO 16.0.13530.2040418 package of statistical functions. \nResults: The main symptom in 100% of cases was chronic cough with production of sputum. Patients were concerned about shortness of breath (91.7%), episodic hemoptysis (29.2%), systemic symptoms (fatigue, weight loss). Hypertonic NaCl solution has a direct mucolytic effect, osmotic and anti-edematous effect. Protection of the mucous membrane of the respiratory tract makes hyaluronic acid an ideal additional component of hypertonic saline solution. All patients showed a positive effect of treatment immediately. After 2 weeks, the respiratory rate decreased, the FEV1 index increased at 8.6 (p&lt;0.05), SpO2 increased up to 93.75 \u00b1 7.13%, the number of points according to the SGRQ decreased, BODE index also decreased \nConclusions: Leading clinical signs of bronchiectasis were: a chronic cough with daily sputum production (100% of patients), shortness of breath (91.7%). The use of nebulizer inhalations decreased shortness of breath at 17.6% (\u0440&lt;0.05), improved external respiratory function indices (FVCL increased at 9.7% (\u0440&lt;0.01), FEV1 at 8.6% (\u0440&lt;0.01)) and blood oxygen saturation increased at 4.9% (\u0440&lt;0.05)). The offered complex increased tolerance to physical exertion (the 6-minute walk test and 4-year survival (BODE prognostic index)<\/jats:p>","DOI":"10.36740\/wlek202306112","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T12:17:45Z","timestamp":1689769065000},"page":"1406-1412","source":"Crossref","is-referenced-by-count":0,"title":["BRONCHIECTASIS IN ADULT PATIENTS: CLINICAL PECULIARITIES AND APPROACHES TO THE TREATMENT"],"prefix":"10.36740","volume":"76","author":[{"given":"Viktoriia","family":"Rudnyk","sequence":"first","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliia","family":"Chaplynska","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liubov","family":"Skrypnyk","sequence":"additional","affiliation":[{"name":"IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","unstructured":"1. Anaev EKh. Modern approaches to the treatment of bronchiectasis in adults. Practical pulmonology. 2017; 4: 30-38."},{"key":"ref1","unstructured":"2. National clinical guidelines. Suppurative lung diseases. http:\/\/ksgs.mz.mosreg.ru\/sites\/default\/files\/doc\/thoracic-surgeon-kr004.pdf. [date access 15.12.2022]."},{"key":"ref2","unstructured":"3. Zaitsev AA, Sinopalnikov AI. Management of adult patients with bronchiectasis (based on the recommendations of the European Respiratory Society). Practical pulmonology. 2018; 4: 36-54."},{"key":"ref3","unstructured":"4. Terpigorev SA. Bronchiectasis in clinical practice: current state of the problem. Practical pulmonology. 2017; 4: 28-39."},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"5. European Respiratory Society guidelines for the management of adult bronchiectasis. European Respiratory Journal. 2017; 50: 1700629. doi: 10.1183\/13993003.00629-2017.","DOI":"10.1183\/13993003.00629-2017"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. MRC Dyspnoea scale\/MRC Breathlessness scale. https:\/\/mrc.ukri.org\/research\/facilities-and-resources-for-researchers\/mrc-scales\/mrc-dyspnoea-scale-mrc-breathlessness-scale\/# definition. [date access 15.12.2022].","DOI":"10.1093\/occmed\/kqx086"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. 6-min test \u2013 ATS Statement Guidelines for the Six-Minute Walk Test. https:\/\/www.atsjournals.org\/doi\/10.1164\/ajrccm.166.1.at1102. [date access 15.12.2022].","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Mosenifar Z. What is the BODE index, and how is used to estimate the prognosis of chronic obstructive pulmonary disease (COPD)? https:\/\/www.medscape.com\/answers\/297664-7357\/what-is-the-bode-index-and-how-is-used-to-estimate-the-prognosis-of-chronic-obstructive-pulmonary-disease-copd. [date access 15.12.2022].","DOI":"10.3109\/15412555.2012.661000"},{"key":"ref8","unstructured":"9. St. George\u2019s Respiratory Questionnaire (SGRQ). [https:\/\/www.thoracic.org\/members\/assemblies\/assemblies\/srn\/questionaires\/sgrq. php. [date access 15.12.2022]."},{"key":"ref9","unstructured":"10. Kovalenko SV. The use of Lorde Hyper solution in nebulizer therapy of patients with pulmonary profile. Health of Ukraine of the 21st century. 2016; 22 (395): 54-55."},{"key":"ref10","unstructured":"11. Seliuk MM. Respiratory tract infections: treatment in the light of modern views. http:\/\/www.health-medix.com\/articles\/ misteztvo\/2019-07-11\/5.pdf [date access 15.12.2022]."}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T12:21:48Z","timestamp":1689769308000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2023\/WiadLek2023i6.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023,6]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202306112","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}