{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:55:26Z","timestamp":1778666126217,"version":"3.51.4"},"reference-count":30,"publisher":"ALUNA","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>The aim: To evaluate the potential protective effect of Eprosartan (ARB) in bilateral renal IRI in male rats. \nMaterials and methods: 20 Sprague-Dawley rats divided into four groups. Sham group had surgery without IRI. Control group was subjected to 30 min ischemia and 2 hours of reperfusion. Vehicle group received 14 ml\/kg (IP) injection of solvent mixture containing (10% DMSO, 40% PEG300, 5% Tween-80, and 45% normal saline) 30 minutes before clamping. Eprosartan-treated group with 30 mg\/kg Eprosartan intraperitoneally 30 min before occlusion of renal pedicles followed by 30 minutes of ischemia and 2 hours of reperfusion. Serum BUN and Creatinine used to assess renal function. Renal tissue was used to measure the levels of TNF-\u03b1, IL-1\u03b2, IL-6, F2-isoprostane, and Caspase3 were measured by assessment of renal tissue. Histopathological examinations were conducted to detect parenchymal damage. \nResults: Mean serum levels of BUN and Creatinine as well as mean renal tissue levels of TNF-\u03b1, IL-1\u03b2, IL-6, F2-isoprostane, and Caspase3 were significantly increased in control and vehicle groups together with increase in histological damage score compared to sham group, whereas treatment of rats with Eprosartan resulted in significant reduction in mean serum levels of BUN and Creatinine and mean renal tissue levels of TNF-\u03b1, IL-1\u03b2, IL-6, F2-isoprostane, and Caspase3 and obvious reduction in tissue injury. \nConclusions: This study demonstrates that Eprosartan pretreatment enhances kidney function by decreasing serum BUN and Creatinine, oxidative stress, cytokines, and apoptotic markers.<\/jats:p>","DOI":"10.36740\/wlek202307110","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:08:11Z","timestamp":1692965291000},"page":"1576-1585","source":"Crossref","is-referenced-by-count":5,"title":["PROTECTIVE EFFECT OF EPROSARTAN IN RENAL ISCHEMIA REPERFUSION INJURY BY REGULATING OXIDATIVE STRESS, INFLAMMATION, AND APOPTOTIC CASCADES IN A BILATERAL RAT MODEL"],"prefix":"10.36740","volume":"76","author":[{"given":"Haidar Hameed Ali","family":"Al-Sultany","sequence":"first","affiliation":[{"name":"PHARMACOLOGY AND THERAPEUTICS DEPARTMENT, FACULTY OF PHARMACY, UNIVERSITY OF KUFA, KUFA, IRAQ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murooj L.","family":"Altimimi","sequence":"additional","affiliation":[{"name":"PHARMACOLOGY AND THERAPEUTICS DEPARTMENT, FACULTY OF PHARMACY, UNIVERSITY OF KUFA, KUFA, IRAQ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najah Rayish","family":"Hadi","sequence":"additional","affiliation":[{"name":"DEPARTMENT OF PHARMACOLOGY AND THERAPEUTICS, FACULTY OF MEDICINE, UNIVERSITY OF KUFA, NAJAF, IRAQ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Shang Y, Madduma Hewage S, Wijerathne CUB et al. Kidney Ischemia-Reperfusion Elicits Acute Liver Injury and Inflammatory Response. Front Med (Lausanne). 2020;7:201. doi: 10.3389\/fmed.2020.00201.","DOI":"10.3389\/fmed.2020.00201"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"2. Bai T, Wang X, Qin C et al. Deficiency of mindin reduces renal injury after ischemia reperfusion. Mol Med. 2022;28(1):152. doi: 10.1186\/ s10020-022-00578-2.","DOI":"10.1186\/s10020-022-00578-2"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Amin SN, Sakr HI, El Gazzar WB et al. Combined saline and vildagliptin induced M2 macrophage polarization in hepatic injury induced by acute kidney injury. PeerJ. 2023;11:e14724. doi: 10.7717\/peerj.14724.","DOI":"10.7717\/peerj.14724"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Abousaad S, Ahmed F, Abouzeid A et al. Meprin \u03b2 expression modulates the interleukin-6 mediated JAK2-STAT3 signaling pathway in ischemia\/reperfusion-induced kidney injury. Physiol Rep. 2022;10(18):e15468. doi: 10.14814\/phy2.15468.","DOI":"10.14814\/phy2.15468"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Buys-Gon\u00e7alves GF, Abreu LAS, Gregorio BM et al. Antioxidants as Renoprotective Agents for Ischemia during Partial Nephrectomy. Biomed Res Int. 2019;2019:8575398. doi: 10.1155\/2019\/8575398.","DOI":"10.1155\/2019\/8575398"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Jung HY, Oh SH, Ahn JS et al. NOX1 Inhibition Attenuates Kidney Ischemia-Reperfusion Injury via Inhibition of ROS-Mediated ERK Signaling. Int J Mol Sci. 2020;21(18):6911. doi: 10.3390\/ijms21186911.","DOI":"10.3390\/ijms21186911"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Han SJ, Lee HT. Mechanisms and therapeutic targets of ischemic acute kidney injury. Kidney Res Clin Pract. 2019;38(4):427-440. doi: 10.23876\/j.krcp.19.062.","DOI":"10.23876\/j.krcp.19.062"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Peng YJ, Lu JW, Lee CH et al. Cardamonin Attenuates Inflammation and Oxidative Stress in Interleukin-1\u03b2-Stimulated Osteoarthritis Chondrocyte through the Nrf2 Pathway. Antioxidants (Basel). 2021;10(6):862. doi: 10.3390\/antiox10060862.","DOI":"10.3390\/antiox10060862"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Ustunova S, Takir S, Yilmazer N et al. Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia\/Reperfusion Injury in Isolated Rat Heart. In Vivo. 2020;34(5):2507-2516. doi: 10.21873\/invivo.12067.","DOI":"10.21873\/invivo.12067"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Hashmi SF, Rathore HA, Sattar MA et al. Hydrogen Sulphide Treatment Prevents Renal Ischemia-Reperfusion Injury by Inhibiting the Expression of ICAM-1 and NF-kB Concentration in Normotensive and Hypertensive Rats [published correction appears in Biomolecules. 2022;12(4):593]. Biomolecules. 2021;11(10):1549. doi: 10.3390\/biom11101549.","DOI":"10.3390\/biom11101549"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Qi W, Boliang W, Xiaoxi T et al. Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling. Biomed Pharmacother. 2020;122:109547. doi: 10.1016\/j.biopha.2019.109547.","DOI":"10.1016\/j.biopha.2019.109547"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Sayed AM, Gohar OM, Abd-Alhameed EK et al. The importance of natural chalcones in ischemic organ damage: Comprehensive and bioinformatic analysis review. J Food Biochem. 2022;46(10):e14320. doi: 10.1111\/jfbc.14320.","DOI":"10.1111\/jfbc.14320"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. El-Naga RN. Pre-treatment with cardamonin protects against cisplatin-induced nephrotoxicity in rats: impact on NOX-1, inflammation and apoptosis. Toxicol Appl Pharmacol. 2014;274(1):87-95. doi: 10.1016\/j.taap.2013.10.031.","DOI":"10.1016\/j.taap.2013.10.031"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Peng S, Hou Y, Yao J et al. Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage. Food Funct. 2017;8(3):997-1007. doi: 10.1039\/c7fo00054e.","DOI":"10.1039\/c7fo00054e"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Li Y, Qin Y, Yang C et al. Cardamonin induces ROS-mediated G2\/M phase arrest and apoptosis through inhibition of NF-\u03baB pathway in nasopharyngeal carcinoma [retraction of: Cell Death Dis. 2017 Aug 31;8(8):e3024]. Cell Death Dis. 2019;10(4):289. doi: 10.1038\/s41419- 019-1482-8.","DOI":"10.1038\/cddis.2017.407"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Barber K, Mendonca P, Soliman KFA. The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer\u2019s Disease. Brain Sci. 2023;13(1):145. doi: 10.3390\/brainsci13010145.","DOI":"10.3390\/brainsci13010145"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Ahmad A. Prophylactic Treatment with Hydrogen Sulphide Can Prevent Renal Ischemia-Reperfusion Injury in L-NAME Induced Hypertensive Rats with Cisplatin-Induced Acute Renal Failure. Life (Basel). 2022;12(11):1819. doi: 10.3390\/life12111819.","DOI":"10.3390\/life12111819"},{"key":"ref17","unstructured":"18. Abbas WJ, Altemimi ML, Al-Mudhafar RH et al. Effects of vinpocetine on renal ischemia reperfusion injury in a male rat model. Syst Rev Pharm. 2020;11(12):2380-2389."},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Hassanlou AA, Jamali S, RayatSanati K et al. Cannabidiol modulates the METH-induced conditioned place preference through D2-like dopamine receptors in the hippocampal CA1 region. Brain Res Bull. 2021;172:43-51. doi: 10.1016\/j.brainresbull.2021.04.007.","DOI":"10.1016\/j.brainresbull.2021.04.007"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Nouri K, Anooshe M, Karimi-Haghighi S et al. Involvement of Hippocampal D1-Like Dopamine Receptors in the Inhibitory Effect of Cannabidiol on Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference. Neurochem Res. 2021;46(8):2008- 2018. doi: 10.1007\/s11064-021-03350-w.","DOI":"10.1007\/s11064-021-03350-w"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Khanegheini A, Khani M, Zarrabian S et al. Cannabidiol enhanced the development of sensitization to the expression of methamphetamine-induced conditioned place preference in male rats. J Psychiatr Res. 2021;137:260-265. doi: 10.1016\/j.jpsychires.2021.02.045.","DOI":"10.1016\/j.jpsychires.2021.02.045"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Wang J, Xiong M, Fan Y et al. Mecp2 protects kidney from ischemia-reperfusion injury through transcriptional repressing IL-6\/STAT3 signaling. Theranostics. 2022;12(8): 3896-3910. doi: 10.7150\/thno.72515.","DOI":"10.7150\/thno.72515"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23. Machado DI, de Oliveira Silva E, Ventura S, et al. The Effect of Curcumin on Renal Ischemia\/Reperfusion Injury in Diabetic Rats [published correction appears in Nutrients. 2022;14(22):4835]. Nutrients. 2022;14(14):2798. doi: 10.3390\/nu14142798.","DOI":"10.3390\/nu14224835"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24. Ma DC, Zhang NN, Zhang YN et al. Salvianolic Acids for Injection alleviates cerebral ischemia\/reperfusion injury by switching M1\/M2 phenotypes and inhibiting NLRP3 inflammasome\/pyroptosis axis in microglia in vivo and in vitro. J Ethnopharmacol. 2021;270:113776. doi: 10.1016\/j.jep.2021.113776.","DOI":"10.1016\/j.jep.2021.113776"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Han SJ, Lovaszi M, Kim M et al. P2X4 receptor exacerbates ischemic AKI and induces renal proximal tubular NLRP3 inflammasome signaling. FASEB J. 2020;34(4):5465-5482. doi: 10.1096\/fj.201903287R.","DOI":"10.1096\/fj.201903287r"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"26. Alnfakh ZA, Al-Mudhafar DH, Al-Nafakh RT et al. The anti-inflammatory and antioxidant effects of Montelukast on lung sepsis in adult mice. J Med Life. 2022;15(6):819-827. doi: 10.25122\/jml-2021-0269.","DOI":"10.25122\/jml-2021-0269"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Feng R, Xiong Y, Lei Y et al. Lysine\u2013specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4\/NOX4 pathway in mice. J Cell Mol Med. 2022; 26(15):4254-4267. doi: 10.1111\/jcmm.17444.","DOI":"10.1111\/jcmm.17444"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28. Prem PN, Kurian GA. Fisetin attenuates renal ischemia\/reperfusion injury by improving mitochondrial quality, reducing apoptosis and oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 2022;395(5):547-561. doi: 10.1007\/s00210-022-02204-8.","DOI":"10.21203\/rs.3.rs-937139\/v1"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29. Shan Y, Chen D, Hu B et al. Allicin ameliorates renal ischemia\/reperfusion injury via inhibition of oxidative stress and inflammation in rats. Biomed Pharmacother. 2021;142:112077. doi:10.1016\/j.biopha.2021.112077.","DOI":"10.1016\/j.biopha.2021.112077"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30. Hasanein P, Rahdar A, Barani M et al. Oil-In-Water Micro emulsion Encapsulation of Antagonist Drugs Prevents Renal Ischemia-Reperfusion Injury in Rats. Appl Sci. 2021;11(3),1264. doi: 10.3390\/app11031264.","DOI":"10.3390\/app11031264"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:10:11Z","timestamp":1692965411000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2023\/WLek202307.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202307110","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}