{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:04:24Z","timestamp":1752282264704},"reference-count":29,"publisher":"ALUNA","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>The aim: The objective of the current study was to reveal ultrastructural changes in rats\u2019 thymocytes in experimental data in conditions of mild general dehydration. \nMaterials and methods: The study was conducted on 20 non-linear adult male laboratory rats weighing 150-170 g. Histological and semi-thin slides of the thymus were prepared according to the required guidelines. \nResults: On average, in the cortical zone of the thymus, there was decreased cellularity by 13.4% (p&lt;0.001), while in the medulla zone this indicator turned out to be unreliable - 5.5% (\u0440=0.19), compared to the indicators in animals of the control group. The study showed that a slight degree of general dehydration of the body causes ultrastructural changes in the thymus and is accompanied by a cell-mediated response of the central link of immunogenesis and results in morphological changes in the thymus, which are atrophic in nature with a typical pattern of remodeling of the organ\u2019s microstructure, which corresponds to cellular aging and the associated sign of accelerated involution. \nConclusions: General dehydration of a mild degree in the experiment is accompanied by a cell-mediated response of the central link of immunogenesis and results in morphological changes in the thymus, which are atrophic in nature with a typical pattern of remodeling of the organ\u2019s microstructure, which corresponds to cellular aging and the associated sign of accelerated involution.<\/jats:p>","DOI":"10.36740\/wlek202308101","type":"journal-article","created":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:08:08Z","timestamp":1695550088000},"page":"1709-1716","source":"Crossref","is-referenced-by-count":2,"title":["HISTOULTRASTRUCTURAL FEATURES OF THYMOCYTES DUE TO THE IMPACT OF THE EXPERIMENTAL GENERAL DEHYDRATION OF A MILD DEGREE"],"prefix":"10.36740","volume":"76","author":[{"given":"Olha","family":"Prykhodko","sequence":"first","affiliation":[{"name":"SUMY STATE UNIVERSITY, SUMY, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Avilova","sequence":"additional","affiliation":[{"name":"KYIV MEDICAL UNIVERSITY, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhii","family":"Dmytruk","sequence":"additional","affiliation":[{"name":"SUMY STATE UNIVERSITY, SUMY, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Ponyrko","sequence":"additional","affiliation":[{"name":"SUMY STATE UNIVERSITY, SUMY, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena","family":"Gordienko","sequence":"additional","affiliation":[{"name":"SUMY STATE UNIVERSITY, SUMY, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Prykhodko","sequence":"additional","affiliation":[{"name":"SUMY STATE UNIVERSITY, SUMY, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. 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