{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:04:49Z","timestamp":1698642289967},"reference-count":17,"publisher":"ALUNA","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>The aim: To determine the minimum criteria for early diagnosing PHACE(S) syndrome in neonates and infants with infantile hemangioma (IH) in the max\u00acillofacial area. \nMaterials and methods: A total of 26 asymptomatic children from 20 days to six months of aged with IH of more than 5 cm\u00b2 in the maxillofacial area were included in this study. A medical record of patients clinical examination, Holter monitoring, echocardiographic ultrasound and magnetic resonance imaging (MRI) were analysed. The IH treatment with \u00df-blockers was carried out. \nResults: IH localization was diagnosed: 62% with a lesion of a part facial segment, 23% in one segment, 15% in several segments (p=0.018), and 12% with other parts of the body lesion (p=1.000). The patent foramen ovale was diagnosed in 35% of children. Central nervous system disorders were observed in 12% over two years of age. The indices of Holter monitoring and blood glucose changed in age norm range during treatment. Cardiovascular (the aortic coarctation (p=0.003) and brain (the Dandy-Walker malformation) (p=0.031) abnormalities were determined in two cases (8%) according to the MRI only. We diagnosed PHACE(S) syndrome in both these cases of children, only aged 12 months and 2.5 years old. \nConclusions: Early diagnosis of PHACE(S) syndrome is possible on a contrast-enhanced MRI performed in asymptomatic neonates and infants with the facial several segmental IH with \/ without ulceration (p=0.018, p=0.046; p &lt; 0.05) for recognition of presymptomatic cardiovascular and brain abnormalities.<\/jats:p>","DOI":"10.36740\/wlek202309117","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T18:05:10Z","timestamp":1698602710000},"page":"2021-2027","source":"Crossref","is-referenced-by-count":0,"title":["PHACE(S) SYNDROME - EARLY DIAGNOSTICS IN THE MAXILLOFACIAL AREA"],"prefix":"10.36740","volume":"76","author":[{"given":"Natalia","family":"Kiseilyova","sequence":"first","affiliation":[{"name":"BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyudmila","family":"Yakovenko","sequence":"additional","affiliation":[{"name":"CHILDREN HOSPITAL \u21167, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Tyshko","sequence":"additional","affiliation":[{"name":"CHILDREN HOSPITAL \u21167, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1. 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J Pediatr Endocrinol Metab. 2019;32(8):797-802. doi: 10.1515\/jpem-2019-0126.","DOI":"10.1515\/jpem-2019-0126"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T18:05:16Z","timestamp":1698602716000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2023\/WiadLek2023i9.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":17,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202309117","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}