{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T00:28:24Z","timestamp":1699748904265},"reference-count":9,"publisher":"ALUNA","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>The aim: The study of cytomorphological and cytogenetic features of the buccal epithelium of residents of apartments who complained of unpleasant odors in their homes. \nMaterials and methods: The state of buccal epithelium in residents of multi-story buildings was studied. A total of 237 individuals were examined, 117 males and 120 females, aged from 6 to 81 years. Buccal cells were collected using a sterile spatula and stained with a 2.5% solutionofaceto-orcein and 1% light green. The preparations were examined using a light microscope OPTON Axioskop (Germany) with oil immersion at a magnification of x1000. Statistical processing of the data was performed using IBMSPSS Statistics 29.0.0.0 (t-Student criterion; Mann-Whitney; ANOVA: Tukey; T3-Dunnett), with p\u22640.05. \nResults: Cytomorphological and cytogenetic abnormalities, compared to physiological limits, were mainly manifested as karyorrhexis, nuclear doubling, the appearance of epitheliocytes with perinuclear vacuoles, or nuclear vacuolization. The frequency of micronuclei was observed in the range of (0.3-2.8 \u2030). The highest micronucleus index (per 1000 cells, \u2030) was observed among males aged 15-39 years and females over 65 years old. In both sexes, the lowest micronucleus indices were found in the age group of 6-14 years. \nConclusions: in the \u00absick building\u00bb an increase in the frequency of micronucleus occurrence among males and females was observed simultaneously with increasing age.<\/jats:p>","DOI":"10.36740\/wlek202310116","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T22:01:22Z","timestamp":1699740082000},"page":"2239-2244","source":"Crossref","is-referenced-by-count":0,"title":["AGE AND GENDER-SPECIFIC FEATURES OF CYTOGENETIC CHANGES IN BUCCAL EPITHELIUM IN INDIVIDUALS RESIDING IN THE \u00abSICK BUILDING\u00bb"],"prefix":"10.36740","volume":"76","author":[{"given":"Tetiana S.","family":"Oboronova","sequence":"first","affiliation":[{"name":"L.I. MEDVED\u2019S RESEARCH CENTER OF PREVENTIVE TOXICOLOGY, FOOD AND CHEMICAL SAFETY OF THE MINISTRY OF HEALTH OF UKRAINE, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliia V.","family":"Kurdil","sequence":"additional","affiliation":[{"name":"L.I. MEDVED\u2019S RESEARCH CENTER OF PREVENTIVE TOXICOLOGY, FOOD AND CHEMICAL SAFETY OF THE MINISTRY OF HEALTH OF UKRAINE, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borys I.","family":"Palamar","sequence":"additional","affiliation":[{"name":"BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoriia S.","family":"Lisovska","sequence":"additional","affiliation":[{"name":"L.I. MEDVED\u2019S RESEARCH CENTER OF PREVENTIVE TOXICOLOGY, FOOD AND CHEMICAL SAFETY OF THE MINISTRY OF HEALTH OF UKRAINE, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna M.","family":"Khomenko","sequence":"additional","affiliation":[{"name":"SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petro G.","family":"Zhminko","sequence":"additional","affiliation":[{"name":"L.I. MEDVED\u2019S RESEARCH CENTER OF PREVENTIVE TOXICOLOGY, FOOD AND CHEMICAL SAFETY OF THE MINISTRY OF HEALTH OF UKRAINE, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyudmila A.","family":"Ustinova","sequence":"additional","affiliation":[{"name":"UKRAINIAN MILITARY MEDICAL ACADEMY, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Senel S. An Overview of Physical, Microbiological and Immune Barriers of Oral Mucosa. Int. J. Mol. Sci. 2021;22:7821. doi: 10.3390\/ ijms22157821.","DOI":"10.3390\/ijms22157821"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Groeger S, Meyle J. Oral Mucosal Epithelial Cells. Front. Immunol. 2019;10:208. doi: 10.3389\/fimmu.2019.00208.","DOI":"10.3389\/fimmu.2019.00208"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Sommer S, Buraczewska I, Kruszewski M. Micronucleus Assay: the state of art, and future directions. International Journal of Molecular Sciences. 2020;21:1534-53. doi: 10.3390\/ijms21041534.","DOI":"10.3390\/ijms21041534"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"4. Wang S-S, Tang Y-L, Pang X et al. The maintenance of an oral epithelial barrier. Life Sci. 2019;227:129\u2013136. doi: 10.1016\/j.lfs.2019.04.029.","DOI":"10.1016\/j.lfs.2019.04.029"},{"key":"ref4","unstructured":"5. \u00abPro zatverdzhennya metodychnykh rekomendatsiy \u00abObstezhennya ta rayonuvannya terytoriyi za stupenem vplyvu antropohennykh chynnykiv na stan ob\u2019yektiv dovkillya z vykorystannyam tsytohenetychnykh metodiv\u00bb: Nakaz MOZ Ukrayiny 13.03.2007 \u2116116 [\u201cOn approval of methodological recommendations \u201cSurvey and zoning of the territory according to the degree of influence of anthropogenic factors on the state of environmental objects using cytogenetic methods : \u201cOrder of the Ministry of Health of Ukraine 13.03.2007 No. 116]. https:\/\/zakon.rada.gov.ua\/rada\/show\/v0116282-07#Text. [date access 20.04.2023]. (In Ukrainian)."},{"key":"ref5","unstructured":"6. WHO. Chemical pollution of indoor air and its risk for children\u2019s health: educational course: supplementary publication to the screening tool for assessment of health risks from combined exposure to multiple chemicals in indoor air in public settings for children. https:\/\/ apps.who.int\/iris\/handle\/10665\/341984 [date access 20.04.2023]."},{"key":"ref6","unstructured":"7. WHO. Methods for sampling and analysis of chemical pollutants in indoor air: supplementary publication to the screening tool for assessment of health risks from combined exposure to multiple chemicals in indoor air in public settings for children. https:\/\/apps.who. int\/iris\/handle\/10665\/334389 [date access 20.04.2023]."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Lin W-T, Chen C-Y, Lee C-C et al. Air Phthalate Emitted from Flooring Building Material by the Micro-Chamber Method: Two-Stage Emission Evaluation and Comparison. Toxics. 2021;9:216. doi: 10.3390\/toxics9090216.","DOI":"10.3390\/toxics9090216"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Kaewrat J, Janta R, Sichum S et al. Indoor Air Quality and Human Health Risk Assessment in the Open-Air Classroom. Sustainability. 2021;13:8302. doi: 10.3390\/su13158302.","DOI":"10.3390\/su13158302"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T22:01:26Z","timestamp":1699740086000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2023\/WLek202310.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":9,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202310116","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}