{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T15:23:10Z","timestamp":1702653790430},"reference-count":15,"publisher":"ALUNA","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wiad Lek"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>The aim: To investigate changes in the characteristics of menstrual function in women after suffering from Covid-19 or vaccination against SARS-CoV-2. \nMaterials and methods: After the retrospective analysis of 378 medical records patients were divided into: Group 1 (177 women) with menstrual function disorders (MFD) after COVID-19, Group 2 (121 women) with MFD after SARS-CoV-2 vaccination, Group C (80 women) without MFD after COVID-19 or vaccination (controls). The study focused on the clinical and hormonal menstrual cycle characteristics and factors influencing MFD. \nResults: Dyshormonal thyroid disorders were observed in 63.0% of Group 1 and 45.7% of Group 2 patients; hyperprolactinemia - in 31.0% and 39.4%, hyper\u00acestrogenia - in 50% and 21%, and hyperandrogenism - in 39% and 20%. MFD was associated with hyperandrogenism with concurrent hyperprolactinemia, in the context of thyroid dysfunction; and with changes of gonadotropin production, along with normal and elevated estrogen concentrations and worsening of mental health that suggest disruption of central regulatory and feedback mechanisms in the pituitary-thyroid-ovarian system under the stressors influence. \nConclusions: There are changes in the menstrual cycle associated with disruption of the hypothalamus-pituitary-ovary system and thyroid function in women after suffering from Covid-19 or vaccination. To reestablish reproductive homeostasis, employing a personalized diagnostic strategy is recommended, encompassing the evaluation of thyroid gland status, hormonal profiling, and the consideration of psychosocial facets.<\/jats:p>","DOI":"10.36740\/wlek202310118","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T22:01:15Z","timestamp":1699740075000},"page":"2252-2257","source":"Crossref","is-referenced-by-count":1,"title":["CLINICAL PROFILES AND CHARACTERISTICS OF MENSTRUAL DYSFUNCTION IN WOMEN AFTER SUFFERING FROM COVID-19 OR VACCINATION"],"prefix":"10.36740","volume":"76","author":[{"given":"Alla O.","family":"Petruk","sequence":"first","affiliation":[{"name":"STATE INSTITUTION OF SCIENCE \u201cRESEARCH AND PRACTICAL CENTER OF PREVENTIVE AND CLINICAL MEDICINE\u201d STATE ADMINISTRATIVE DEPARTMENT, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena O.","family":"Lytvak","sequence":"additional","affiliation":[{"name":"STATE INSTITUTION OF SCIENCE \u201cRESEARCH AND PRACTICAL CENTER OF PREVENTIVE AND CLINICAL MEDICINE\u201d STATE ADMINISTRATIVE DEPARTMENT, KYIV, UKRAINE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22436","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","unstructured":"1. WHO. Coronavirus (COVID-19) Dashboard. https:\/\/covid19.who.int\/. [date access 17.05.2023]"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Talic S, Shah S, Wild H et al. Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-nalysis. The British Medical Journal. 2021;375:e068302. doi:10.1136\/bmj-2021- 068302.","DOI":"10.1136\/bmj-2021-068302"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. McGinty EE, Presskreischer R, Han H et al. Psychological Distress and Loneliness Reported by US Adults in 2018 and April 2020. Journal of the American Medical Association. 2020;324(1):93\u20134. doi: 10.1001\/jama.2020.9740.","DOI":"10.1001\/jama.2020.9740"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Rossetti CL, Cazarin J, Hecht F et al. COVID-19 and thyroid function: What do we know so far? Front Endocrinol (Lausanne). 2022;13:1041676. doi: 10.3389\/fendo.2022.1041676.","DOI":"10.3389\/fendo.2022.1041676"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Jacobson MH, Howards PP, Darrow LA et al. Thyroid hormones and menstrual cycle function in a longitudinal cohort of premenopausal women. Paediatr Perinat Epidemiol. 2018; 32: 225-234. doi: 10.1111\/ppe.12462.","DOI":"10.1111\/ppe.12462"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Lebar V, Lagan\u00e0 AS, Chiantera V et al. The Effect of COVID-19 on the Menstrual Cycle: A Systematic Review. Journal of Clinical Medicine. 2022;11(13):3800. doi: 10.3390\/jcm11133800.","DOI":"10.3390\/jcm11133800"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Rodr\u00edguez Quejada L, Toro Wills MF, Mart\u00ednez-\u00c1vila MC et al. Menstrual cycle disturbances after COVID-19 vaccination. Womens Health (Lond). 2022;18:17455057221109375. doi: 10.1177\/17455057221109375.","DOI":"10.1177\/17455057221109375"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Pierce M, Hope H, Ford T et al. Mental health before and during the COVID-19 pandemic: a longitudinal probability sample survey of the UK population. Lancet Psychiatry. 2020;7(10):883\u201392. doi: 10.1016\/S2215-0366(20)30308-4.","DOI":"10.1016\/s2215-0366(20)30308-4"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Lytvak O, Petruk A. Clinical and morphological aspects of the reproductive system of reproductive age women with menstrual disorders after COVID-19. Clinical and Preventive Medicine. 2022;3(21):4-10. doi: 10.31612\/2616-4868.3(21).2022.01.","DOI":"10.31612\/2616-4868.3(21).2022.01"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Pan D, Sze S, Minhas JS et al. The impact of ethnicity on clinical outcomes in COVID-19: A systematic review. EClinicalMedicine. 2020;23:100404. doi: 10.1016\/j.eclinm.2020.100404.","DOI":"10.1016\/j.eclinm.2020.100404"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"11. Navarro VM, Kaiser UB. Metabolic influences on neuroendocrine regulation of reproduction. Curr Opin Endocrinol Diabetes Obes. 2013;20(4):335\u201341. doi: 10.1097\/MED.0b013e32836318ce.","DOI":"10.1097\/MED.0b013e32836318ce"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Ilyaev B, Muminiy SN, Borukh E et al. COVID-Induced Hyperthyroidism in a 30-Year-Old Female: A Case Study. Cureus. 2023;15(6):e40851. doi:10.7759\/cureus.40851.","DOI":"10.7759\/cureus.40851"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. \u00c7abuk SA, Cevher AZ, K\u00fc\u00e7\u00fckardal\u0131 Y. Thyroid Function During and After COVID-19 Infection: A Review. touch REV Endocrinol. 2022;18(1):58- 62. doi: 10.17925\/EE.2022.18.1.58.","DOI":"10.17925\/ee.2022.18.1.58"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Medina-Perucha L, L\u00f3pez-Jim\u00e9nez T, Holst AS et al. Self-Reported Menstrual Alterations During the COVID-19 Syndemic in Spain: A Cross-Sectional Study. Int J Womens Health. 2022;14:529-544. doi:10.2147\/IJWH.S354655.","DOI":"10.2147\/ijwh.s354655"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"15. Rahman SA, Grant LK, Gooley JJ et al. Endogenous Circadian Regulation of Female Reproductive Hormones. The Journal of Clinical Endocrinology and Metabolism. 2019;104(12):6049\u201359. doi: 10.1210\/jc.2019-00803.","DOI":"10.1210\/jc.2019-00803"}],"container-title":["Wiadomo\u015bci Lekarskie"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T22:01:19Z","timestamp":1699740079000},"score":1,"resource":{"primary":{"URL":"https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2023\/WLek202310.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":15,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.36740\/wlek202310118","archive":["Internet Archive"],"relation":{},"ISSN":["0043-5147"],"issn-type":[{"value":"0043-5147","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}